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DFKBP-1

CAT: 0804-HY-103634-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103634-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF of FKBP12, the Thalidomide based Cereblon ligand and a linker[1].
CAS Number
1799711-22-0
UNSPSC
12352005
Target
FKBP; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-bet-degrader-8.html
Purity
98.00
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C([C@H]1N(C(C(C(C)(C)CC)=O)=O)CCCC1)O[C@@H](C2=CC=CC(NC(CCC(NCCCCNC(COC3=CC=CC(C(N4C(CC5)C(NC5=O)=O)=O)=C3C4=O)=O)=O)=O)=C2)CCC6=CC=C(OC)C(OC)=C6
Molecular Formula
C53H64N6O14
Molecular Weight
1009.11
References & Citations
[1]Winter GE, et al. DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation. Science. 2015 Jun 19;348 (6241) :1376-81.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon; FKBP12

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