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4-Octylphenol

CAT: 0804-HY-W130878-01Size: 250 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W130878-01Size:250 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4-Octylphenol is a hormone disruptor that has gender-specific effects on male reproductive cells, significantly reducing the mitotic index and the number of spermatogonia. 4-Octylphenol can cause inflammatory damage to fish gills by activating the complement system through the C3a/C3aR axis and the C5a/C5aR1 axis, this leads to complement activation and causes immune suppression due to the imbalance between Th1/Th2 cells and regulatory T cells (Treg) /Th17 cells, as well as inflammatory damage via the Toll-like receptor 7 (Toll-like Receptor (TLR) ) /IκBα/NF-κB pathway[1][2].
CAS Number
1806-26-4
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Complement System; NF-κB; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/4-octylphenol.html
Purity
98.0
Smiles
CCCCCCCCC1=CC=C(C=C1)O
Molecular Formula
C14H22O
Molecular Weight
206.32
Precautions
H315, H319
References & Citations
[1]E Bendsen, et al. Effect of 4-octylphenol on germ cell number in cultured human fetal gonads. 2001 Feb;16 (2) :236-43.|[2]Qi Sun, et al. Immunosuppression participated in complement activation-mediated inflammatory injury caused by 4-octylphenol via TLR7/IκBα/NF-κB pathway in common carp (Cyprinus carpio) gills. Aquat Toxicol. 2022 Aug:249:106211.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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