4-Octylphenol

CAT: 931-T201798-01Size: 10 mgDry Ice: NoHazardous: No
10 mgSelected
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1806-26-4
Target
NF-?B|||TLR|||Complement System
Related Pathways
Immunology/Inflammation|||NF-?B
Bioactivity
4-Octylphenol is an endocrine disruptor with gender-specific effects on male germ cells, significantly reducing the mitotic index and the number of spermatogonia. It also causes inflammatory damage in the gills of carp by activating the complement system through the C3a/C3a receptor (C3a/C3aR) axis and C5a/C5a receptor 1 (C5a/C5aR1) axis. Furthermore, 4-Octylphenol induces immune suppression by disrupting the balance between helper T (Th) cells 1/Th2 and regulatory T (Treg) /Th17 cells, and triggers inflammatory damage through the Toll-like receptor 7 (Toll-like Receptor (TLR) ) /inhibitor ?B?/nuclear factor ?B (TLR7/I?B?/NF-?B) pathway.
Smiles
OC1=CC=C(C=C1)CCCCCCCC
Molecular Formula
C14H22O
Molecular Weight
206.32
Shipping Conditions
Cool pack
Storage Temperature
-20°C