Methyl oleanonate

• Description :

  Methyl oleanonate is a natural triterpene PPARγ agonist isolated from the species of Pistacia lentiscus var. Chia[1]. Methyl oleanonate is a modified oleanolic acid derivative with anti-cancer effects[2].

• Product Name Alternative :

  3-Oxoolean-12-en-28-oic acid methyl ester

• UNSPSC :

  12352211

• Target :

  PPAR

• Type :

  Natural Products

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/methyl-oleanonate.html

• Purity :

  99.81

• Solubility :

  DMSO : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  CC1(C)C(CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])CC(C)(C)CC[C@@](C(OC)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H])=O

• Molecular Formula :

  C31H48O3

• Molecular Weight :

  468.71

• References & Citations :

  [1]Rasmus K Petersen, et al. Pharmacophore-driven identification of PPARγ agonists from natural sources. J Comput Aided Mol Des. 2011 Feb;25 (2) :107-16.|[2]Barbara Bednarczyk-Cwynar, et al. Anticancer effect of A-ring or/and C-ring modified oleanolic acid derivatives on KB, MCF-7 and HeLa cell lines. Org Biomol Chem. 2012 Mar 21;10 (11) :2201-5

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  PPARγ

• CAS Number :

  [1721-58-0]