STAT1 (His-tagged), human recombinant
-
Catalog number
7889-10
-
Price
Please ask
-
Size
10 ug
-
-
Synonyms
Signal transducer and activator of transcription 1-alpha/beta, Transcription factor ISGF-3 components p91/p84, STAT1
-
Alternative_names
Signal transducer and activator of transcription 1-alpha/beta, Transcription factor ISGF-3 components p91/p84, STAT1
-
Description
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors.
-
Recombinant
Yes
-
Source
E. coli
-
Purity by SDS PAGE
≥90%
-
Assay
SDS-PAGE
-
Molecular Weight
85.2 kDa
-
Storage Temp
-20°C
-
Shipping
Gel pack
-
Shelf Life
12 months
-
Concentration
0.5 mg/ml
-
Appearance
Liquid
-
Physical form description
Liquid
-
Background Information
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
-
Amino acid sequence
Met 1 - Val 712
-
Handling
Centrifuge the vial prior to opening.
-
Usage
For Research Use Only! Not to be used in humans
-
-
Conjugation
histidine
-
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
-
Additional source
Recombinants or rec. proteins
-
Group
recombinants
-
Gene target
-
Gene symbol
STAT1
-
Short name
STAT1 (His-tagged), recombinant
-
Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
-
Label
his-tagged
-
Species
Human, Humans
-
Alternative name
signal transducer and activator on transcription 1, 91kDa (histidine-tagged), H. sapiens Rec.
-
Alternative technique
rec
-
Alternative to gene target
signal transducer and activator of transcription 1, 91kDa, CANDF7 and IMD31A and IMD31B and IMD31C and ISGF-3 and STAT91, STAT1 and IDBG-77617 and ENSG00000115415 and 6772, sequence-specific DNA binding, nuclei, Stat1 and IDBG-153162 and ENSMUSG00000026104 and 20846, STAT1 and IDBG-642654 and ENSBTAG00000007867 and 510814,515988
-
Gene info
MeSH Data
-
Name
-
Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
-
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
-
Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
Similar products
