RAGE Antibody, PE Conjugated

RAGE Antibody, PE Conjugated is available 1 time from Bioss primary conjugated antibodies labs

  • Long name
    RAGE Polyclonal Antibody, PE Conjugated
  • Category
    Conjugated Primary Antibodies
  • Conjugation
    PE
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Target Antigen
    RAGE
  • Specificity
    This is a highly specific antibody against RAGE.
  • Modification
    Unmodified
  • Modification site
    None
  • Clonality
    Polyclonal
  • Clone
    Polyclonal antibody
  • Concentration
    1ug per 1ul
  • Immunogen_range
    140-190/402
  • Subcellular location
    Extracellular
  • Source
    KLH conjugated synthetic peptide derived from rat AGER
  • Gene ID number
    81722
  • Swiss Prot
    Q63495
  • Tested applications
    FCM
  • Recommended dilutions
    FCM(1:20-100)
  • Crossreactivity
    Rat
  • Crossreactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Antigen background
    Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S1A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides (By similarity). Interaction with S1B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.
  • Purification method
    This antibody was purified via Protein A.
  • Storage conditions
    Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
  • Excitation Emission
    480,565nm/578nm
  • Synonyms
    RAGE; Advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end products; Ager
  • Gene target
  • Short name
    RAGE Antibody, PE Conjugated
  • Technique
    Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
  • Label
    PE
  • Alternative name
    RAGE (Antibody to), peroxidase coupled
  • Alternative technique
    antibodies

bs-0177R-PE | RAGE Antibody, PE Conjugatedsize: 0.1ml | 426.73 USD

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