AGER Antibody, Cy3 Conjugated

• Catalog number
  bs-4999R-Cy3
• Price
  Please ask
• Size
  0.1ml

• Long name
  AGER Polyclonal Antibody, Cy3 Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  Cy3
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  AGER
• Specificity
  This is a highly specific antibody against AGER.
• Modification
  Unmodified
• Modification site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen_range
  30-80/404
• Subcellular location
  Extracellular
• Source
  KLH conjugated synthetic peptide derived from human AGER
• Gene ID number
  177
• Swiss Prot
  Q15109
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  512,550nm/570,615nm
• Synonyms
  RAGE; Advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end products; AGER
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser. 1 of the Anti-AGER can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC. This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy.
• Additional conjugation
  cy3 conjugation kit
• French translation
  anticorps

• Gene target
  AGER   Conjugated  
• Gene symbol
  AGER
• Short name
  Anti-AGER
• Technique
  Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
• Isotype
  Immunoglobulin G (IgG)
• Label
  Cy3
• Alternative name
  Anti-AGER PAb Cy3
• Alternative technique
  antibodies
• Alternative to gene target
  advanced glycosylation end product-specific receptor, RAGE, AGER and IDBG-80463 and ENSG00000204305 and 177, S100 protein binding, Extracellular, Ager and IDBG-172144 and ENSMUSG00000015452 and 11596, AGER and IDBG-633065 and ENSBTAG00000014420 and 280986

Gene info

• Identity
  HGNC:320
• Gene
  AGER
• Long gene name
  advanced glycosylation end-product specific receptor
• Synonyms
  • RAGE
  • SCARJ1
  • sRAGE
• Synonyms name
  • receptor for advanced glycation end-products
• GenBank acession
  • M91211
• Locus
  6p21.32
• Discovery year
  1994-10-17
• Entrez gene record
  177
• Pubmed identfication
  • 7713518
• RefSeq identity
  • NM_001136
• Classification
  • Scavenger receptors
  • C2-set domain containing
• VEGA ID
  OTTHUMG00000031120

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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