PHA 665752, MET kinase inhibitor

• Catalog number
  SIH-421-5MG
• Price
  Please ask
• Size
  5 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  477575-56-7
• Description
  MET kinase inhibitor
• Molecular weight
  641,61 g/mol
• Primary research fields
  Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
• Other name
  (2R)-1-[[5-[(Z)-[5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C32H34Cl2N4O4S
• Origin
  Synthetic
• Purity pourcentage
  >98
• Soluble in
  Soluble to 100 mM in DMSO.
• Physical appearance
  Yellow solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Not WHMIS controlled. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
• PubChem number
  10461815
• Scientific context
  PHA 665752 is a potent and selective MET kinase, ATP-competitive inhibitor. It has been studied as an antitumor agent because it has been seen to inhibit tumorigenicity and angiogenesis in mouse lung cancer xenografts.
• Bibliography
  1. Puri N., Khramtsov A., Ahmed S., Nallasura V., Hetzel J., Jagadeeswaran R., et al. (2007) Cancer Res. 3529-34.
• Release date
  21-May-2014
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of PHA 665752 (SIH-421), a MET kinase inhibitor. CAS #: 477575-56-7. Molecular Formula: C32H34Cl2N4O4S. Molecular Weight: 641.61 g/mol. Chemical structure of PHA 665752, a MET kinase inhibitor (SIH-421). CAS # 477575-56-7. Molecular Formula: C32H34Cl2N4O4S.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.005
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  PHA   665752   MET   kinase   inhibitor  
• Gene symbol
  SLTM, MET, TRM-CAT4-3, TRM-CAT5-1, TRM-CAT3-2, TRM-CAT7-1, TRM-CAT5-2, TRM-CAT3-1, TRM-CAT2-1, TRM-CAT4-1
• Short name
  PHA 665752, MET kinase inhibitor
• Alternative name
  PHA 665752, MET phosphorylation catalyst suppressor

Gene info

• Identity
  HGNC:20709
• Gene
  SLTM
• Long gene name
  SAFB like transcription modulator
• Synonyms
  • Met
  • FLJ13213
• GenBank acession
  • BC046119
• Locus
  15q22.1
• Discovery year
  2005-11-08
• Entrez gene record
  79811
• RefSeq identity
  • NM_024755
• Classification
  • RNA binding motif containing
• VEGA ID
  OTTHUMG00000074033

Gene info

• Identity
  HGNC:7029
• Gene
  MET
• Long gene name
  MET proto-oncogene, receptor tyrosine kinase
• Synonyms gene name
  • met proto-oncogene
• Synonyms
  • HGFR
  • RCCP2
  • DFNB97
• Synonyms name
  • hepatocyte growth factor receptor
• GenBank acession
  • M35073
• Locus
  7q31
• Discovery year
  1986-01-01
• Pubmed identfication
  • 1846706
  • 1611909
  • 25941349
• Classification
  • Receptor tyrosine kinases
  • IPT domain containing
• VEGA ID
  OTTHUMG00000023299
• Locus Specific Databases
  • LRG_662

Gene info

• Identity
  HGNC:34959
• Gene
  TRM-CAT4-3
• Long gene name
  tRNA-Met (anticodon CAT) 4-3
• Synonyms gene
  • TRNAM20
• Synonyms gene name
  • transfer RNA methionine 20 (anticodon CAU)
  • transfer RNA-Met (CAT) 4-3
• Synonyms
  • tRNA-Met-CAT-4-3
• GenBank acession
  • HG983956
• Locus
  6p22.2
• Discovery year
  2008-08-29
• Entrez gene record
  107986682
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34869
• Gene
  TRM-CAT5-1
• Long gene name
  tRNA-Met (anticodon CAT) 5-1
• Synonyms gene
  • TRNAM16
• Synonyms gene name
  • transfer RNA methionine 16 (anticodon CAU)
  • transfer RNA-Met (CAT) 5-1
• Synonyms
  • tRNA-Met-CAT-5-1
• GenBank acession
  • HG983957
• Locus
  6p22.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189303
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34673
• Gene
  TRM-CAT3-2
• Long gene name
  tRNA-Met (anticodon CAT) 3-2
• Synonyms gene
  • TRNAM8
• Synonyms gene name
  • transfer RNA methionine 8 (anticodon CAU)
  • transfer RNA-Met (CAT) 3-2
• Synonyms
  • tRNA-Met-CAT-3-2
• GenBank acession
  • HG983953
• Locus
  6p22.1
• Discovery year
  2008-08-29
• Entrez gene record
  100189111
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34645
• Gene
  TRM-CAT7-1
• Long gene name
  tRNA-Met (anticodon CAT) 7-1
• Synonyms gene
  • TRNAM5
• Synonyms gene name
  • transfer RNA methionine 5 (anticodon CAU)
  • transfer RNA-Met (CAT) 7-1
• Synonyms
  • tRNA-Met-CAT-7-1
• GenBank acession
  • HG983959
• Locus
  6p11.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189085
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:54713
• Gene
  TRM-CAT5-2
• Long gene name
  tRNA-Met (anticodon CAT) 5-2
• Synonyms
  • tRNA-Met-CAT-5-2
• Locus
  6p22.2
• Discovery year
  2019-12-06
• Entrez gene record
  107986680
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34779
• Gene
  TRM-CAT3-1
• Long gene name
  tRNA-Met (anticodon CAT) 3-1
• Synonyms gene
  • TRNAM12
• Synonyms gene name
  • transfer RNA methionine 12 (anticodon CAU)
  • transfer RNA-Met (CAT) 3-1
• Synonyms
  • tRNA-Met-CAT-3-1
• GenBank acession
  • HG983952
• Locus
  6p22.1
• Discovery year
  2008-08-29
• Entrez gene record
  100189216
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34697
• Gene
  TRM-CAT2-1
• Long gene name
  tRNA-Met (anticodon CAT) 2-1
• Synonyms gene
  • TRNAM9
• Synonyms gene name
  • transfer RNA methionine 9 (anticodon CAU)
  • transfer RNA-Met (CAT) 2-1
• Synonyms
  • tRNA-Met-CAT-2-1
• GenBank acession
  • HG983951
• Locus
  16q22.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189135
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34661
• Gene
  TRM-CAT4-1
• Long gene name
  tRNA-Met (anticodon CAT) 4-1
• Synonyms gene
  • TRNAM7
• Synonyms gene name
  • transfer RNA methionine 7 (anticodon CAU)
  • transfer RNA-Met (CAT) 4-1
• Synonyms
  • tRNA-Met-CAT-4-1
• GenBank acession
  • HG983954
• Locus
  6p22.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189391
• Classification
  • Cytoplasmic transfer RNAs

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