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Stock availabilitIn Stock
In Stock
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CAS number
167869-21-8
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Description
MEK kinase inhibitor
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Molecular weight
267,3 g/mol
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Primary research fields
Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
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Other name
2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one, PD98059
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C16H13NO3
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Origin
Synthetic
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Purity pourcentage
≥95% (HPLC)
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Soluble in
Soluble in DMSO (6.5 mg/ml); 25 mg/ml in anhydrous DMSO), methanol, dichlormethane and 100% ethanol (0.6 mg/ml)
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Physical appearance
Pale yellow solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Acute toxicity, Oral (Category 3), H301 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301 Toxic if swallowed. Precautionary statements: P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P321 Specific treatment (see supplemental first aid instructions on this label). P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant.
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PubChem number
4713
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Scientific context
PD98059 is a potent, selective and reversible inhibitor of mitogen-activated protein kinase kinase (MAPKK/ MEK-1) activation. Specifically, it binds to the inactive form of MAPKK, blocking its activation, causing inhibition of phosphorylation and the activation of MAP kinase. It has been shown to enhance self-renewal of embryonic stem cells. PD98059 is cell permeable inhibitor.
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Bibliography
1. Alessi D.R., Cuenda A., Cohen P., Dudley D.T., & Saltiel A.R. (1995) J. Biol. Chem. 270(46): 27489–27494. 2. Qi X., et al. (2004) Pro. Nat. Acad. Sci. USA. 101(16): 6027–6032. 3. Dudley D.T., Pang L., Decker S.J., Bridges A.J., & Saltiel A.R. (1995) Pro. Nat. Acad. Sci. USA. 92(17): 7686–7689.
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Release date
1-Oct-2014
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of PD98059 (SIH-466), a MEK kinase inhibitor. CAS #: 167869-21-8. Molecular Formula: C16H13NO3. Molecular Weight: 267.3 g/mol. Chemical structure of PD98059, a MEK kinase inhibitor (SIH-466). CAS # 167869-21-8. Molecular Formula: C16H13NO3.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.005
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
