C4B Antibody

• Catalog number
  F40031-0.4ML
• Price
  Please ask
• Size
  0.4 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  C4B
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000
• Notes
  Titration of the C4B antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This C4B antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P0C0L4
• Purity
  Antigen affinity
• Description
  This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9.
• Immunogen
  A portion of amino acids 655-684 from the human protein was used as the immunogen for this C4B antibody.
• Storage
  Aliquot the C4B antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  C4B  
• Gene symbol
  C4B-AS1, C4B, C4A
• Short name
  Anti-C4B
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to C4B
• Alternative technique
  antibodies
• Alternative to gene target
  complement component 4B (Chido blood group), C4B_2 and C4B1 and C4B12 and C4B2 and C4B3 and C4B5 and C4BD and C4F and CH and CO4 and CPAMD3, C4B and IDBG-301132 and ENSG00000224389 and 100293534,721, carbohydrate binding, Extracellular

Gene info

• Identity
  HGNC:39752
• Gene
  C4B-AS1
• Long gene name
  C4B antisense RNA 1
• Synonyms gene name
  • C4B antisense RNA 1 (non-protein coding)
• Locus
  6p21.33
• Discovery year
  2011-04-21
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000137467

Gene info

• Identity
  HGNC:1324
• Gene
  C4B
• Long gene name
  complement C4B (Chido blood group)
• Synonyms gene name
  • complement component 4B
  • complement component 4B (Chido blood group)
• Synonyms
  • CPAMD3
  • C4F
  • CO4
  • C4B1
  • C4B3
  • CH
• GenBank acession
  • AF019413
• Locus
  6p21.33
• Discovery year
  2001-06-22
• Entrez gene record
  721
• RefSeq identity
  • NM_001002029
• Classification
  • C3 and PZP like, alpha-2-macroglobulin domain containing
  • Blood group antigens
  • Complement system activation components
• VEGA ID
  OTTHUMG00000031187
• Locus Specific Databases
  • LRG_138

Gene info

• Identity
  HGNC:1323
• Gene
  C4A
• Long gene name
  complement C4A (Rodgers blood group)
• Synonyms gene name
  • complement component 4A
  • complement component 4A (Rodgers blood group)
• Synonyms
  • CPAMD2
  • C4S
  • CO4
  • C4
  • C4A3
  • C4A2
  • C4A4
  • C4A6
  • C4B
  • RG
• GenBank acession
  • L26261
  • M14823
  • X77491
  • AY224378
• Locus
  6p21.33
• Discovery year
  2001-06-22
• Entrez gene record
  720
• RefSeq identity
  • NM_007293
• Classification
  • C3 and PZP like, alpha-2-macroglobulin domain containing
  • Blood group antigens
  • Complement system activation components
• VEGA ID
  OTTHUMG00000031186
• Locus Specific Databases
  • LRG_137

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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