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Products_type
Antibody
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Products_short_name
[CD37]
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Products_name_syn
[Cell differentiation antigen 37; GP52 40; Tetraspanin-26; Tspan-26; TSPAN26]
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Other_names
[leukocyte antigen CD37 isoform B; Leukocyte antigen CD37; leukocyte antigen CD37; CD37 molecule; Tetraspanin-26; Tspan-26; CD_antigen: CD37]
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Products_gene_name
[CD37]
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Other_gene_names
[CD37; CD37; GP52-40; TSPAN26; TSPAN26; Tspan-26]
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Clonality
Monoclonal
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Clone
[IPO-24]
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Reactivity
Human
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Specificity
Recognizes a protein of 33-55kDa, identified as CD37 (Workshop V; Code CD37.7). CD37 is strongly expressed on normal and neoplastic mature (sIg+) B-lymphocytes. In B-cell ontogeny, CD37 appears after the pre-B-cell stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells.1 CD37 is also present, at low densities, on resting and activated T cells, neutrophils, monocytes, and some myelomonocytic leukemia cells. It is absent from platelets, erythrocytes. CD37 is a member of a family of tetraspan transmembrane proteins, including CD9, CD53, CD63, CD81, and CD82. It associates other tetraspan transmembrane proteins and MHC class II molecules to form a large complex at the surface of B cells and play a role in signal transduction. CD37 is a valuable and stable marker for peripheral mature B-cells and corresponding malignancies like B-cell chronic lymphocytic leukemia (B-CLL), hairy cell leukemia (HCL), and all types of B-cell non-Hodgkin's lymphoma (B-NHL).
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Form
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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Storage_stability
Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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Tested_application
Functional Studies, Flow Cytometry (FC/FACS), Immunofluorescence (IF)
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Properties
If you buy Antibodies supplied by MyBioSource they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Description
For cells, cell lines and tissues in culture till half confluency.
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About
Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
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Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus
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French translation
anticorps
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Gene target
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Gene symbol
CD37
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Short name
CD37 (Peripheral Mature B- ) Mouse Monoclonal Antibody
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Technique
Mouse monoclonal, Antibody, Mouse, antibodies against human proteins, antibodies for, Component cell markers and DNA bp. markers are genetic markers er genes or DNA sequences with a known location on a chromosome that can be used to identify individuals or species. Protein markers in kDA. Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
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Host
Mouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
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Isotype
IgG2b, kappa
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Species
Mouse, Mouses
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Alternative name
CD37 molecule (Peripheral Mature B-cellular detection labelled) Mouse monoclonal (antibody to-)
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Alternative technique
antibodies, murine
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Alternative to gene target
CD37 molecule, GP52-40 and TSPAN26, CD37 and IDBG-62489 and ENSG00000104894 and 951, protein binding, Cell surfaces, Cd37 and IDBG-182311 and ENSMUSG00000030798 and 12493, CD37 and IDBG-640486 and ENSBTAG00000011421 and 508751
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Tissue
cell
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