STAT3 Inhibitor VII

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Cas number

1041438-68-9
Chemical s molecular weight

444.26
Chemical s main applications

STAT3 Inhibitor VII is a cellular JAK1/JAK2/TYK2/STAT3 activation inhibitor.
Chemical s formula

C19H7F7N2O3
Physical properties

No Data Available
Melting temperature

No Data Available
Boiling temperature

No Data Available
Chemical s soluble in

No Data Available
Stability conditions

No Data Available
Storage

No Data Available
Chemical s specifications
Description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Gene target

STAT3 Inhibitor VII
Gene symbol

STAT3, MARCHF7, IGLVVII-41-1, SYT7
Short name

STAT3 Inhibitor VII
Alternative name

signal transducer and activator on transcription 3 (acute-phase response factor) suppressor VII
Alternative to gene target

signal transducer and activator of transcription 3 (acute-phase response factor), ADMIO and APRF and HIES, STAT3 and IDBG-50702 and ENSG00000168610 and 6774, protein dimerization activity, nuclei, Stat3 and IDBG-211637 and ENSMUSG00000004040 and 20848, STAT3 and IDBG-640197 and ENSBTAG00000021523 and 101910056,508541

Identity

HGNC:11364
Gene

STAT3
Long gene name

signal transducer and activator of transcription 3
Synonyms gene name
- signal transducer and activator of transcription 3 (acute-phase response factor)
Synonyms
- APRF
GenBank acession
- BC014482
Locus

17q21.2
Discovery year

1995-11-08
Entrez gene record

6774
Pubmed identfication
- 7512451
RefSeq identity
- NM_139276
- NM_003150
Classification
- SH2 domain containing
VEGA ID

OTTHUMG00000150645
Locus Specific Databases
- STAT3base: Mutation registry for Hyper-IgE syndrome
- LRG_112

Identity

HGNC:17393
Gene

MARCHF7
Long gene name

membrane associated ring-CH-type finger 7
Synonyms gene
- AXOT
- MARCH7
Synonyms gene name
- axotrophin
- membrane-associated ring finger (C3HC4) 7
- membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
Synonyms
- MARCH-VII
- RNF177
GenBank acession
- AK022973
Locus

2q24.2
Discovery year

2001-12-17
Entrez gene record

64844
Pubmed identfication
- 14722266
RefSeq identity
- NM_022826
Classification
- Ring finger proteins
- Membrane associated ring-CH-type fingers
VEGA ID

OTTHUMG00000132029

Identity

HGNC:15691
Gene

IGLVVII-41-1
Long gene name

immunoglobulin lambda variable (VII)-41-1 (pseudogene)
Synonyms gene name
- immunoglobulin lambda variable (VII)-41-1
- immunoglobulin lambda variable (VII)-41-1 pseudogene
Synonyms
- IGLV(VII)-41-1
GenBank acession
- X99568
Locus

22q11.22
Discovery year

2001-05-15
Entrez gene record

84089
RefSeq identity
- NG_000002
Classification
- Immunoglobulin lambda locus at 22q11.2
VEGA ID

OTTHUMG00000151296