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Alternative name1
Anti-Kininogen, High MW (High Molecular Weight Kininogen, HMWK, KNG, Kininogen 1, Kininogen-1, KNG1, Alpha-2-thiol Proteinase Inhibitor, BDK, Fitzgerald Factor, Williams-Fitzgerald-Flaujeac Factor)
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Alternative name2
Kininogen, High MW (High Molecular Weight Kininogen, HMWK, KNG, Kininogen 1, Kininogen-1, KNG1, Alpha-2-thiol Proteinase Inhibitor, BDK, Fitzgerald Factor, Williams-Fitzgerald-Flaujeac Factor)
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Alternative name3
Kininogen, High MW (High Molecular Weight Kininogen, HMWK, KNG, Kininogen 1, Kininogen-1, KNG1, Alpha-2-thiol Proteinase Inhibitor, BDK, Fitzgerald Factor, Williams-Fitzgerald-Flaujeac Factor)
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Alternative name4
Kininogen, High MW
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Alternative name5
Anti -Kininogen, High MW (High Molecular Weight Kininogen, HMWK, KNG, Kininogen 1, Kininogen-1, KNG1, Alpha-2-thiol Proteinase Inhibitor, BDK, Fitzgerald Factor, Williams-Fitzgerald-Flaujeac Factor)
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Other names
kininogen II,high MW; N/A
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Gene name
N/A
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Gene name synonims
N/A
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Other gene names
N/A
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Category
Antibodies
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Clonality
Polyclonal
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Immunoglobulin isotype
IgG
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Clone
Polyclonal antibody
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Host organism
Host: Goat; Source: Human
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Species reactivity
Human
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Specificity and cross reactivity
Recognizes human high molecular weight kininogen. In immunoelectrophoresis, bi-dimensional electrophoresis and radial immunodiffusion (Ouchterlony, Mancini) against normal plasma, one single precipitin line is obtained. No precipitation is observed against plasma of patients with high molecular weight kininogen deficiency, but its presence can be demonstrated in normal serum. In double radial immunodiffusion the precipitin line obtained against normal plasma shows a reaction of full identity with the precipitin line with purified high molecular weight kininogen. Does not crossreact with any other human plasma proteins.
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Purification method
Serum
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Form Appearance
Supplied as a lyophilized powder. Preservative free. Reconstitute with 1ml sterile ddH2O. Dilute further in PBS, pH 7.2.
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Concentration
N/A
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Storage and shipping
Lyophilized powder may be stored productone should be stored at -20 degrees Celsius.. Stable for 12 months productone should be stored at -20 degrees Celsius.. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. For optimal long term storage, productone should be kept at -20 degrees Celsius. Reconstituted product is stable for 12 months productone should be stored at -20 degrees Celsius.. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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Tested for
ELISA (EL/EIA)
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Description
productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against. Properly used, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in. Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, they are inexpensive to manufacture and respectively to buy, the time needed for production is considerably shorter. Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions. To obtain more detailed information on productone, please, refer to the full product datasheet.
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Advisory
In order to retain the quality and the affinity of productone unchanged, please, avoid cycles of freezing and thawing. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
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Additional description
The Kininogen, MW ( Molecular Weight Kininogen, HMWK, KNG, Kininogen 1, Kininogen-1, KNG1, Alpha-2-thiol Proteinase Inhibitor, BDK, Fitzgerald Factor, Williams-Fitzgerald-Flaujeac Factor) is a α- or alpha protein sometimes glycoprotein present in blood. Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbol
KNG1, MIR1289-2, MIR521-2, MIR509-2, MIR512-2, MIR7-2, MIR329-2, RNU6-2, KRTAP13-2, SNORD114-2
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Short name
Kininogen, MW ( Molecular Weight Kininogen, HMWK, KNG, Kininogen 1, Kininogen-1, KNG1, Alpha-2-thiol Proteinase Inhibitor, BDK, Fitzgerald Factor, Williams-Fitzgerald-Flaujeac Factor)
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Alternative name
Kininogen, High MW (High Molecular Weight Kininogen, HMWK, KNG, Kininogen 1, Kininogen-1, kininogen 1, a-2-thiol Proteinase suppressor, BDK, Fitzgerald Factor, Williams-Fitzgerald-Flaujeac Factor)
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Alternative to gene target
kininogen 1, BDK and BK and KNG, KNG1 and IDBG-69059 and ENSG00000113889 and 3827, zinc ion binding, Extracellular, KNG1 and IDBG-634652 and ENSBTAG00000005122 and 280833
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