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Stock availabilitIn Stock
In Stock
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CAS number
103745-39-7
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Description
ROCK inhibitor
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Molecular weight
327,83 g/mol
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Primary research fields
Cell Signaling, Neuroscience
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Other name
1-(5-Isoquinolinylsulfonyl) homopiperazine hydrochloride; 5-(1,4-Diazepan-1-ylsulfonyl)isoquinoline
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C14H17N3O2S•HCl
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Origin
Synthetic
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Purity pourcentage
≥98% (TLC); NMR (Conforms)
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Soluble in
May be dissolved in DMSO (75 mg/ml) or water (100 mg/ml)
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Physical appearance
Powder
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
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PubChem number
3547
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Scientific context
Fasudil is a ROCK2 inhibitor with some action on PRK2 and MSK1 (IC50 values are 1.9 µM, 4 µM and 5 µM respectively). It is also shown to inhibit RSK1, RSK2, PKA, AMPK and PKd1. It is also a calcium channel antagonist and vasodilator.
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Bibliography
1. Shirotani M., et al. (1991) J. Pharmacol. Exp. Ther. 259(2): 738-744. 2. Arai M., Nozawa R., et al. (1993) Biochem. Pharmacol. 46(8): 1487-1490. 3. Satoh S., et al. (1996) Br. J. Pharmacol. 118(7): 1592-1606. 4. Sward K., et al. (2000) J. Physiol. 522: 33-49.
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Release date
4-Apr-2013
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Fasudil (SIH-371), a ROCK inhibitor. CAS #: 103745-39-7. Molecular Formula: C14H17 N3O2S•HCl. Molecular Weight: 327.83 g/mol. Chemical structure of Fasudil, a ROCK inhibitor (SIH-371). CAS # 103745-39-7. Molecular Formula: C14H17 N3O2S•HCl.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.05
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
