-
Stock availabilitIn Stock
In Stock
-
CAS number
146986-50-7
-
Description
ROCK kinase inhibitor
-
Molecular weight
320,3 g/mol
-
Primary research fields
Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
-
Other name
Y-27632 dihydrochloride, (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide . 2HCl
-
Product category
Small Molecules
-
Product type
Inhibitor
-
Chemical formula
C14H23Cl2N3O
-
Origin
Synthetic
-
Purity pourcentage
≥98% (HPLC)
-
Soluble in
Soluble in DMSO (25 mg/ml), methanol (25 mg/ml), acetonitrile (
-
Physical appearance
White to pale yellow powder
-
Storage recommendations
-20ºC
-
Shipping recommendations
Shipped Ambient
-
Safety information
Classification: Acute toxicity, Oral (Category 4), H302 Acute toxicity, Inhalation (Category 4), H332 Acute toxicity, Dermal (Category 4), H312 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ protective clothing. P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P322 Specific measures (see supplemental first aid instructions on this label). P330 Rinse mouth. P363 Wash contaminated clothing before reuse. P501 Dispose of contents/ container to an approved waste disposal plant.
-
PubChem number
448042
-
Scientific context
Y 27632 is a very potent and selective ROCK1 and ROCK2 inhibitor. Y 27632 is cell permeable and is an ATP competitive inhibitor.
-
Bibliography
1. Shi J., et al. (2013) Cell Death & Disease, 4: e483.
-
Release date
1-Oct-2014
-
PubMed number
Refer to PubMed
-
Tested applications
To be tested
-
Tested reactivity
To be tested
-
-
Representative figure legend
Chemical structure of Y 27632 (SIH-486), a ROCK family kinase inhibitor. CAS #: 146986-50-7. Molecular Formula: C14H23Cl2N3O. Molecular Weight: 320.3 g/mol. Chemical structure of Y 27632, a ROCK family kinase inhibitor (SIH-486). CAS # 146986-50-7. Molecular Formula: C14H23Cl2N3O.
-
Warning information
Non-hazardous
-
Country of production
Canada
-
Total weight kg
0.25
-
Net weight g
0.005
-
-
Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
