DR6 Cytoplasmic Domain Recombinant Protein

DR6 Cytoplasmic Domain Recombinant Protein is available 1 time from Proscience labs

  • Keep at
    Store in working aliquots at -70˚C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
  • NCBI ID
    27242
  • Protein is used in
    E, WB, MS
  • Activity
    not available
  • Source
    Homo sapiens
  • Protein's origin
    Mouse
  • Uniprot
    O75509
  • Recombinant in
    E. coli
  • Vial
    Liquid
  • SEQUENCE
    aa 371 - 655
  • Gene name
    tumor necrosis factor receptor superfamily, member 21
  • Pureity
    ~95%
  • Accession nr
    NP_055267
  • About recombinant protein
    Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several death receptors including DR3, DR4, DR5, and DR6 have been identified. Like TNF-R1, DR6 (also known as TNFRSF21) interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed in human tissues and cell lines (2). Recently, DR6 was found to interact with an amino-terminal fragment of the Beta-amyloid protein (APP) in neurons, activating a caspase 6-dependent apoptotic event leading to axonal degeneration and pruning (3). The doublet observed in the SDS-PAGE is likely due to incomplete removal of the signal sequence.
  • His tag on the recombinant protein
    Fusion Partner: C-terminal His-tag
  • KDa of reombinant
    36 kDa (Calculated)
  • Use of recmbinant
    This recombinant protein can be used for WB, ELISA, MS and neutralization assays. For research use only.
  • Suspention medium
    1X PBS containing 10% glycerol
  • Rec. PROTEIN GI#
    7657039
  • About
    Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
  • Other name of the recombinant
    DR6 Antibody: DR6, CD358, BM-018, DR6, UNQ437/PRO868, Tumor necrosis factor receptor superfamily member 21, Death receptor 6
  • Gene target
  • Gene symbol
    TNFRSF21
  • Short name
    DR6 Cytoplasmic Domain Recombinant Protein
  • Technique
    Recombinant
  • Alternative name
    DR6 Cytoplasmic Domain recombinant Protein
  • Alternative technique
    rec

95-119 | DR6 Cytoplasmic Domain Recombinant Proteinsize: 0.05 mg | 399.72 USD

  • Catalog number
    95-119
  • Supplier
  • Price
    399.72 USD
  • Size
    0.05 mg
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
0. Gene info
MeSH Data
  • Name
  • Concept
    Scope note:The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
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