DR6 Extracellular Domain Recombinant Protein
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Catalog number95-120
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PricePlease ask
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Size0.05 mg
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About recombinant proteinApoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several death receptors including DR3, DR4, DR5, and DR6 have been identified. Like TNF-R1, DR6 (also known as TNFRSF21) interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-B and JNK. DR6 is widely expressed in human tissues and cell lines (2). Recently, DR6 was found to interact with an amino-terminal fragment of the Beta-amyloid protein (APP) in neurons, activating a caspase 6-dependent apoptotic event leading to axonal degeneration and pruning (3).
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Other name of the recombinantDR6 Antibody: DR6, CD358, BM-018, DR6, UNQ437/PRO868, Tumor necrosis factor receptor superfamily member 21, Death receptor 6
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Recombinant inE. coli
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His tag on the recombinant proteinFusion Partner: C-terminal His-tag
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SEQUENCEaa 42 - 349
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Activitynot available
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Use of recmbinantThis recombinant protein can be used for WB, ELISA, MS and neutralization assays. For research use only.
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Protein is used inE, WB, MS
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Suspention medium1X PBS containing 10% glycerol
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Keep atStore in working aliquots at -70˚C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
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Rec PROTEIN GI7657039
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Accession nrNP_055267
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KDa of reombinant36 kDa (Calculated)
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Pureity~95%
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AboutProducts are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
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Protein s originMouse
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VialLiquid
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NCBI ID27242
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Gene nametumor necrosis factor receptor superfamily, member 21
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SourceHomo sapiens
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UniprotO75509
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolTNFRSF21
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Short nameDR6 Extracellular Domain Recombinant Protein
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. proscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Alternative nameDR6 Extracellular Domain Rec. Protein
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Alternative techniquerec
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Gene info
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Identity
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Gene
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Long gene nameTNF receptor superfamily member 21
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Synonyms gene name
- tumor necrosis factor receptor superfamily, member 21
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2001-07-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Tumor necrosis factor receptor superfamily
- CD molecules
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VEGA ID
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data