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Target antigen
COX1/Cyclooxygenase 1
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human Predicted to work with: mouse, rat
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Analyses
WB,IHC-P
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Immunogen
E.coli-derived human COX1 recombinant protein (Position: E318-L599). Human COX1 shares 90% and 89% amino acid (aa) sequence identity with mouse and ratCOX1, respectively.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the COX1/Cyclooxygenase 1 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The COX1/Cyclooxygenase 1 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
Cyclooxygenase 1(COX1), also known as Prostaglandin-endoperoxide synthase (PTGS1) or mitochondrial cytochrome c oxidase subunit 1, is the key enzyme in prostaglandin biosynthesis. The gene was approximately 40 kb long, with 11 protein-coding exons. There were 599 amino acid residues with a calculated molecular mass of approximately 68 kD. By analysis of a human/hamster somatic hybrid DNA panel, it was demonstrated that the PTGS1 gene maps to chromosome 9. Human prostaglandin endoperoxide synthase exhibited 91% amino acid identity with the sheep enzyme. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.
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Related articles
1. Yokoyama, C.; Tanabe, T. : Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme. Biochem. Biophys. Res. Commun. 165: 888-894, 1989. 2. Langenbach, R.; Morham, S. G.; Tiano, H. F.; Loftin, C. D.; Ghanayem, B. I.; Chulada, P. C.; Mahler, J. F.; Lee, C. A.; Goulding, E. H.; Kluckman, K. D.; Kim, H. S.; Smithies, O. : Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell 83: 483-492, 1995.
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Gene Name
PTGS1
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Protein Name
Prostaglandin G/H synthase 1
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Gene Full Name
prostaglandin-endoperoxide synthase 1
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Synonyms
COX 1 antibody|COX 3 antibody|COX-1 antibody|COX1 antibody|COX3 antibody|Cyclooxygenase 1 antibody|Cyclooxygenase 3, included antibody|Cyclooxygenase-1 antibody|Cyclooxygenase1 antibody|EC 1.14.99.1 antibody|Partial COX1 proteins, included antibody|PCOX 1 antibody|PCOX1 antibody|PGG/HS antibody|PGH synthase 1 antibody|PGH1_HUMAN antibody|PGHS 1 antibody|PGHS-1 antibody|PGHS1 antibody|PHS 1 antibody|PHS1 antibody|Prostaglandin endoperoxide synthase 1 antibody|Prostaglandin G/H synthase 1 antibody|Prostaglandin G/H synthase and cyclooxygenase antibody|Prostaglandin H Synthase 1 antibody|Prostaglandin H2 synthase 1 antibody|Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) antibody|Prostaglandin-endoperoxide synthase 1 antibody|PTGHS antibody|PTGS 1 antibody|PTGS1 antibody
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Uniprot ID
P23219
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
