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Chemical available in other sizes
Please inquire size and price
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Stock availability
In Stock
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Cas number
556813-39-9
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Chemical s molecular weight
486.31
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Chemical s main applications
A glycogen synthase kinase-3 (GSK-3) inhibitor. Effects of GSK inhibitors on p-tau, GSK-3β activities and cell death were measured in a human neuronal cell line (LUHMES). Lithium and CHIR98014 reduced tau phosphorylation (Ser396) in the cortex and hippocampus. Inhibition of GSK-3 is recently regarded as one of the viable approaches to therapy for Alzheimer's disease, cancer, diabetes mellitus, osteoporosis, and bipolar mood disorder.
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Chemical s category
Amines, Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
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Other name
N6-[2-[[4-(2,4-Dichlorophenyl)-5-(1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro- 2,6-pyridinediamine;
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Chemical s formula
C20H17Cl2N9O2
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Physical properties
Yellow Solid
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Melting temperature
192-196°C (dec.)
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Boiling temperature
No Data Available
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Chemical s soluble in
DMSO, Methanol
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Stability conditions
No Data Available
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Storage
Refrigerator
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