CHIR 99021

• Catalog number
  1677-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile; CT99022
• Description
  A potent and highly selective inhibitor of glycogen synthase kinase-3β (GSK-3β) (IC₅₀ = 6.7 nM). CHIR99021 has been shown to allow for long-term expansion of murine embryonic stem cells in a chemically-defined medium in conjunction with MEK/MAPK inhibitor PD184352 and fibroblast growth factor receptor (FGFR) inhibitor SU5402.
• CAS Number
  252917-06-9
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₂H₁₈Cl₂N₈
• Molecular Weight
  465.34
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO ( 100 mM)
• Handling
  Protect from air and moisture
• Tag Line
  A GSK-3β inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  RT
• Shelf Life
  24 months
• MDL Number
  MFCD12546133
• PubChem CID
  9956119
• PubChem CID Link
• SMILES
  CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N
• InChi
  InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32)
• InChi Key
  AQGNHMOJWBZFQQ-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  CHIR   99021  
• Short name
  CHIR 99021
• Alternative name
  CHIR 99021

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