Camptothecin, Topoisomerase I inhibitor

• Catalog number
  SIH-242-1G
• Price
  Please ask
• Size
  1 g

• Stock availabilitIn Stock
  In Stock
• CAS number
  7689-03-4
• Description
  Topoisomerase I inhibitor
• Molecular weight
  348,36 g/mol
• Primary research fields
  Cancer, Apoptosis
• Other name
  (4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C20H16N2O4
• Origin
  Synthetic
• Purity pourcentage
  >98%
• Soluble in
  Soluble to 5 mM in DMSO
• Physical appearance
  Yellow solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible) Risk Phrases: R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed R46 - May cause heritable genetic damage Hazard Phrases: H302
• PubChem number
  24360
• Scientific context
  Camptothecin is a cytotoxic quinoline alkaloid which inhibits the DNA enzyme topoisomerase I. It binds to the topo I and DNA complex, resulting in a tertiary comlex which stabilizes it. This prevents re-ligation and therefore causes DNA damage which results in apoptosis (1-3). It has showed remarkable anti-cancer activity in clinical trials.
• Bibliography
  1. Adams D.J., et al. (2005) Cancer Chem and Pharm. 57(2): 145-154. 2. Redinbo M.R., Stewart L., Kuhn P., Champoux J.J. and Hol W.G.J. (1998) Science. 279:1504-1513. 3. Pommier Y., et al. (2003) Mutat Res. 532: 173-203.
• Release date
  8-Apr-2011
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Camptothecin (SIH-242), a Topoisomerase I inhibitor. CAS #: 7689-03-4. Molecular Formula: C20H16N2O4. Molecular Weight: 348.36 g/mol. Chemical structure of Camptothecin, a Topoisomerase I inhibitor (SIH-242). CAS # 7689-03-4. Molecular Formula: C20H16N2O4.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  1
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  Camptothecin   Topoisomerase   inhibitor  
• Short name
  Camptothecin, Topoisomerase I inhibitor
• Alternative name
  Camptothecin, Topoisomerase I suppressor

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