(S)-(-)-Bay K 8644

• Catalog number
  B3011-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  (S)-(-)-BAY K 8644; (-)-(S)-BayK8644; (-)-BAY-k-8644; methyl (4S)-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate
• Description
  (S)-(-)-Bay K 8644 is a L-type Ca channel agonist while R-(+)-Bay K8644 is an antagonist. (S)-(-)-Bay K 8644 causes a left shift in the Q1 (activation charge) vs. V activation curve at nanomolar concentrations in guinea-pig ventricular myocytes. The (−)-enantiomer has vasoconstricting and positive inotropic properties. (−)-Bay K 8644 also enhances the force of contraction and prolongs the action potential duration measured at 50% of repolarization in guinea-pig papillary muscles at normal resting potential. (−)-S-BAY K 8644 impairs rotarod and motor activity with an ED₅₀ value of 0.5 mg/kg in mice. It enables reprogramming of Oct4/Klf4-transduced mouse embryonic fibroblasts.
• CAS Number
  98625-26-4
• Structure Available
  1
• Molecular Formula
  C₁₆H₁₅F₃N₂O₄
• Molecular Weight
  356.3
• Cell Permeable
  1
• Purity
  >98%
• Solubilities
  ~20 mg/ml in DMSO and DMF
• Handling
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Tag Line
  An L-type Ca channel agonist
• Storage Condition
  -20ºC
• Shipping Condition
  RT
• Shelf Life
  36 months
• MDL Number
  MFCD00153769
• PubChem CID
  6603728
• PubChem CID Link
• SMILES
  CC1=C(C(C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC
• InChi
  InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3/t13-/m0/s1
• InChi Key
  ZFLWDHHVRRZMEI-ZDUSSCGKSA-N
• Data Sheet Link
• MSDS Available
  1

• Gene target
  Bay   8644  
• Short name
  (S)-(-)-Bay K 8644
• Alternative name
  (S)-(-)-Bay K 8644

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