BAY 11-7085

• Catalog number
  B2329-50
• Price
  Please ask
• Size
  50 mg

• Alternative_name
  (E)-3-(4-t-Butylphenylsulfonyl)-2-propenenitrile,3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-2E-propenenitrile
• Description
  An irreversible inhibitor of IκBα phosphorylation, preventing activation of NF-κB by cytokines and lipopolysaccharide (IC50 = 10 μM). It prevents gene expression that is regulated through the classical pathway of NF-κB activation and thus blocks apoptosis, cell adhesion, and inflammation.
• CAS Number
  196309-76-9
• Structure Available
  Yes
• Molecular Formula
  C₁₃H₁₅NO₂S
• Molecular Weight
  249.33
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  >20 mg/ml (EtOH) in 0,>20 mg/ml (DMSO) in 0
• Handling
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Tag Line
  An irreversible inhibitor of TNF-α-induced IκBα phosphorylation
• Storage Condition
  -20ºC
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• MDL Number
  MFCD01862602
• PubChem CID
  5353432
• PubChem CID Link
• SMILES
  CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)C=CC#N
• InChi
  InChI=1S/C13H15NO2S/c1-13(2,3)11-5-7-12(8-6-11)17(15,16)10-4-9-14/h4-8,10H,1-3H3/b10-4+
• InChi Key
  VHKZGNPOHPFPER-ONNFQVAWSA-N
• Data Sheet Link
• MSDS Available
  1

• Gene target
  BAY   11-7085  
• Gene symbol
  PIRC52, IGKV1OR2-11, PIRC51, PIRC50, SNORD114-11, SNORD116-11, SNORD115-11, IGHV3OR16-11
• Short name
  BAY 11-7085
• Alternative name
  BAY 11-7085

Gene info

• Identity
  HGNC:37556
• Gene
  PIRC52
• Long gene name
  piwi-interacting RNA cluster 52
• Locus
  11
• Discovery year
  2009-11-05
• Entrez gene record
  100313791
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:5768
• Gene
  IGKV1OR2-11
• Long gene name
  immunoglobulin kappa variable 1/OR2-11 (pseudogene)
• Synonyms gene name
  • immunoglobulin kappa variable 1/OR2-11
  • immunoglobulin kappa variable 1/OR2-11 pseudogene
• Synonyms
  • IGKV1/OR2-11
• GenBank acession
  • X51885
• Locus
  2q11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28863
• Pubmed identfication
  • 2111145
• Classification
  • Immunoglobulin kappa (IGK) orphons
• VEGA ID
  OTTHUMG00000184518

Gene info

• Identity
  HGNC:37555
• Gene
  PIRC51
• Long gene name
  piwi-interacting RNA cluster 51
• Locus
  11
• Discovery year
  2009-11-05
• Entrez gene record
  100313860
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37554
• Gene
  PIRC50
• Long gene name
  piwi-interacting RNA cluster 50
• Locus
  11
• Discovery year
  2009-11-05
• Entrez gene record
  100313814
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:32999
• Gene
  SNORD114-11
• Long gene name
  small nucleolar RNA, C/D box 114-11
• Synonyms
  • 14q(II-11)
• Locus
  14q32.31
• Discovery year
  2006-09-26
• Entrez gene record
  767589
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003204.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:33077
• Gene
  SNORD116-11
• Long gene name
  small nucleolar RNA, C/D box 116-11
• Synonyms
  • HBII-85-11
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033423
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003326
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:33030
• Gene
  SNORD115-11
• Long gene name
  small nucleolar RNA, C/D box 115-11
• Synonyms
  • HBII-52-11
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033448
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003303.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:5635
• Gene
  IGHV3OR16-11
• Long gene name
  immunoglobulin heavy variable 3/OR16-11 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable 3/OR16-11
  • immunoglobulin heavy variable 3/OR16-11 pseudogene
• Synonyms
  • IGHV3/OR16-11
• GenBank acession
  • Z29608
• Locus
  16p11.2
• Discovery year
  2000-04-17
• Entrez gene record
  28305
• Classification
  • Immunoglobulin heavy (IGH) orphons
• VEGA ID
  OTTHUMG00000184731

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