EYA1 Antibody
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Catalog numberbs-20158R
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Price:
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Size0.1ml
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Long nameEYA1 Primary Polyclonal Antibody
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Also known asEYA1 PAb
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CategoryPrimary Antibodies
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ConjugationUnconjugated
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Target AntigenEYA1
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SpecificityThis is a highly specific antibody against EYA1.
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Modification sNone
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Modification site sUnmodified antibody
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ClonalityPolyclonal antibody
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Clone numberPolyclonal antibody
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Concentration1ug per 1ul
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Immunogen range260-310/592
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Subcellular locationCytoplasm, Nucleus
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SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human EYA1
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Gene ID number2138
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Swiss ProtQ99502
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Tested ApplicationsIHC-P, IF(IHC-P)
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Recommended dilutionsIHC-P(1:100-500), IF(IHC-P)(1:50-200)
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Cross reactivityHuman, Rat
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the target antigenFunctions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears. Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2.
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Purification methodThis antibody was purified via Protein A.
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Storage conditionsKeep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
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Synonym namesBOP; BOR; BOS1; OFC1; Eyes absent homolog 1; EYA1
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PropertiesIf you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolEYA1
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Short nameAnti-EYA1
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TechniqueAntibody, antibodies against human proteins, antibodies for
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HostRabbit (Oryctolagus cuniculus)
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IsotypeImmunoglobulin G (IgG)
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Alternative nameEYA1 Polyclonal Antibody
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Alternative techniqueantibodies
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Alternative to gene targeteyes absent homolog 1 (Drosophila), BOP and BOR and BOS1 and OFC1, EYA1 and IDBG-25014 and ENSG00000104313 and 2138, metal ion binding, nuclei, Eya1 and IDBG-134456 and ENSMUSG00000025932 and 14048, EYA1 and IDBG-644711 and ENSBTAG00000011298 and 511188
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Gene info
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Identity
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Gene
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Long gene nameEYA transcriptional coactivator and phosphatase 1
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Synonyms gene
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Synonyms gene name
- eyes absent (Drosophila) homolog 1
- eyes absent homolog 1 (Drosophila)
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GenBank acession
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Locus
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Discovery year1996-12-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- EYA transcriptional coactivator and phosphatases
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data