anti-Cullin 1 Antibody

• Catalog number
  49-412
• Price
  Please ask
• Size
  0.05 mL

• Gene info
  Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination, as well as binding to various specificity factors to recruit substrates. Cullin 1 is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, cul1 serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. Cul1 may also contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Cul1 is part of the SCF complex consisting of CUL1, RBX1, SKP1 and SKP2, where it interacts directly with SKP1, SKP2 and RBX1. Cul1 also interacts with RNF7 and is part of a complex with TIP120A/CAND1 and RBX1. The unneddylated form interacts with TIP120A/CAND1 and the interaction negatively regulates the association with SKP1 in the SCF complex.
• Gene names
  CUL1, Cullin 1, Cullin-1, CUL-1
• Antibodie s label
  unlabelled serum
• Purity
  Delipidation and Defibrination
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Antigen
  Cullin 1 antibody was made against amino acids from the C-Terminus of Cullin 1 (Human).
• Immuno application
  ELISA, Western Blot, immuno-histo-chemistry, immuno precipitation
• Antibody advice
  Cullin 1 antibody can be used in ELISA starting at 1:000 - 1:1000, and immunohistochemistry starting at 10 ug/mL.
• Suspention pH azide
  0.01% sodium azide.
• Keep at
  Store Cullin 1 antibody at 4 grades C or -20 grades C. As with all antibodies avoid freeze/thaw cycles.
• Works with
  Human
• Omim nr
  19863257
• Ncbi nr
  Q13616
• Vial with antibody
  in solution
• NCBI GENE nr
  8454
• GENE symbol
  CUL1
• Antigene name
  cullin 1
• Source
  Homo sapiens
• Protein nr
  Q13616
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Cullin  
• Gene symbol
  CUL1P1, CUL1, CUL4AP1
• Short name
  anti-Cullin 1 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toCullin 1 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:49567
• Gene
  CUL1P1
• Long gene name
  cullin 1 pseudogene 1
• Locus
  5q23.2
• Discovery year
  2014-01-15
• Entrez gene record
  100288463
• VEGA ID
  OTTHUMG00000163286

Gene info

• Identity
  HGNC:2551
• Gene
  CUL1
• Long gene name
  cullin 1
• GenBank acession
  • U58087
• Locus
  7q36.1
• Discovery year
  1998-10-29
• Entrez gene record
  8454
• Pubmed identfication
  • 8681378
• RefSeq identity
  • NM_003592
• Classification
  • Cullins
  • SCF complex
• VEGA ID
  OTTHUMG00000152776
• Locus Specific Databases
  • LRG_1407

Gene info

• Identity
  HGNC:44027
• Gene
  CUL4AP1
• Long gene name
  cullin 4A pseudogene 1
• Locus
  4q26
• Discovery year
  2012-05-28
• Entrez gene record
  100129008
• VEGA ID
  OTTHUMG00000161138

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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