Rabbit anti SMO (Smoothened Homolog)

• Catalog number
  X2333P
• Price
  Please ask
• Size
  10MinibLots

• Category
  Primary Antibodies
• Long description
  SMO is a G protein-coupled receptor (GPCR) that putatively associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. The binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). In basal cell carcinoma there are two somatic mutations SMO, D473-> H473 and R562 ->Q562.
• Antibody come from
  Synthetic peptide derived from human FOXP3 protein
• Other description
  Provided as solution in phosphate buffered saline. Antigen Immunoaffiinity Purification
• Clone
  Polyclonal
• Antigen antibody binding interaction
  Rabbit anti SMO (Smoothened Homolog) Antibody
• Antibody is raised in
  Rabbit
• Antibody s reacts with
  Human
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  No Data Available
• Application
  Western blot
• Antibody s suited for
  For use with FOXP3 polyclonal antibodies (Cat. No. X2347P & X2348P).
• Storage
  -20ºC
• Relevant references
  1. Bennett, C.L., et al. 'The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.; Nat. Genet. 27:20-21(2001)._x000B__x000B_2. Wildin, R.S., et al. 'X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy.; Nat. Genet. 27:18-20(2001)._x000B__x000B_3. Brunkow, M.E., et al. 'Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.; Nat. Genet. 27:68-73(2001).
• Protein number
  see ncbi
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• About
  Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
• Latin name
  Oryctolagus cuniculus

• Gene target
  SMO   Smoothened   Homolog  
• Gene symbol
  SMO, SMOX
• Short name
  Rabbit anti SMO (Smoothened Homolog)
• Technique
  Rabbit, anti, antibody to
• Host
  Rabbit, Rabbits
• Isotype
  not specified
• Label
  unlabeled
• Alternative name
  production species: rabbit antibody to smoothened, frizzled family receptor (Smoothened Homolog)
• Alternative technique
  rabbit-anti, antibodies
• Alternative to gene target
  smoothened, frizzled family receptor, FZD11 and Gx and SMOH, SMO and IDBG-40669 and ENSG00000128602 and 6608, Wnt-activated receptor activity, Cell surfaces, Smo and IDBG-132261 and ENSMUSG00000001761 and 319757, SMO and IDBG-635317 and ENSBTAG00000013287 and 539308

Gene info

• Identity
  HGNC:11119
• Gene
  SMO
• Long gene name
  smoothened, frizzled class receptor
• Synonyms gene
  • SMOH
• Synonyms gene name
  • smoothened (Drosophila) homolog
  • smoothened homolog (Drosophila)
  • smoothened, seven transmembrane spanning receptor
  • smoothened, frizzled family receptor
• Synonyms
  • FZD11
• Synonyms name
  • frizzled family member 11
• GenBank acession
  • U84401
• Locus
  7q32.1
• Discovery year
  1996-12-18
• Entrez gene record
  6608
• Pubmed identfication
  • 9628830
• RefSeq identity
  • NM_005631
• Classification
  • G protein-coupled receptors, Class F frizzled
• VEGA ID
  OTTHUMG00000158421
• Locus Specific Databases
  • LRG_1393

Gene info

• Identity
  HGNC:15862
• Gene
  SMOX
• Long gene name
  spermine oxidase
• Synonyms gene
  • C20orf16
• Synonyms gene name
  • chromosome 20 open reading frame 16
• Synonyms
  • FLJ20746
  • dJ779E11.1
  • PAO
  • PAOh1
  • MGC1010
  • SMO
• GenBank acession
  • AK000753
• Locus
  20p13
• Discovery year
  2001-06-21
• Entrez gene record
  54498
• Pubmed identfication
  • 11454677
  • 12398765
• RefSeq identity
  • NM_175842
• VEGA ID
  OTTHUMG00000031777

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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