Rabbit anti Integrin antibody beta 3 (platelet glycoprotein IIIa antibody antigen CD61) (ITGB3)
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Catalog numberX2177P
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Price:
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Size50 μg
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CategoryPrimary Antibodies
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Long descriptionIntegrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
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Antibody come fromExtracellular domain of human
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Other descriptionPhosphate buffered saline containing 0.1% sodium azide. Immunoaffinity Purification
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ClonePolyclonal
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Antigen antibody binding interactionRabbit anti Integrin antibody beta 3 (platelet glycoprotein IIIa antibody antigen CD61) (ITGB3) Antibody
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Antibody is raised inRabbit
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Antibody s reacts withHuman
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Antibody s reacts with these speciesThis antibody doesn't cross react with other species
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Antibody s specificityNo Data Available
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ApplicationImmunohistochemistry-Paraffin
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Antibody s suited forOptimal concentration should be evaluated by serial dilutions.
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StorageLong term: -70ºC; Short term: +4ºC
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Relevant referencesno information yet
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Protein numbersee ncbi
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WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antigens are peptides or recombinant or native dependent on the production method. Platelets, also called thrombocytes or cloth cells in blood and are needed to stop bleeding by clumping and clotting the blood the vessels when the an injury occurs. Teh bone marrow will produce the platelets that have no nucleus. Platelates are unique to mammals, the are curved shaped 1900nm to 3100 nm large nucleus free clothing structures.
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PropertiesIf you buy Antibodies supplied by nordc they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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AboutRabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin nameOryctolagus cuniculus
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French translationanticorps
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Gene target
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Gene symbolITGB3
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Short nameRabbit anti Integrin antibody beta 3 (platelet glycoprotein IIIa antibody antigen CD61) (ITGB3)
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TechniqueAntibody, antigen, Rabbit, anti, antibody to, antibodies against human proteins, antibodies for, antigenes
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HostRabbit, Rabbits
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Isotypenot specified
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Labelunlabeled
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Alternative nameproduction species: rabbit antibody to Integrin (antibody to-) b 3 (platelet glycoprotein IIIa (antibody to-) protein CD61) (integrin, b 3 (platelet glycoprotein IIIa, antigen CD61))
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Alternative techniqueantibodies, antigenes, rabbit-anti
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Alternative to gene targetintegrin, beta 3 (platelet glycoprotein IIIa, antigen CD61), BDPLT16 and BDPLT2 and CD61 and GP3A and GPIIIa and GT, ITGB3 and IDBG-547297 and ENSG00000259207 and 3690, cell adhesion molecule binding, nuclei
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Gene info
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Identity
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Gene
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Long gene nameintegrin subunit beta 3
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Synonyms gene
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Synonyms gene name
- integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
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Synonyms
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Synonyms name
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Locus
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Discovery year1988-06-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- CD molecules
- Integrin beta subunits
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data