- Catalog numberX2184P
- Product nameRabbit anti Integrin antibody beta 3 (platelet glycoprotein IIIa antibody antigen CD61) (ITGB3)
- Size50 μg
- PriceAsk For Price
- CategoryPrimary Antibodies
- Long descriptionIntegrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
- Antibody come fromN-terminal domain of human
- Other descriptionPhosphate buffered saline containing 0.1% sodium azide. Immunoaffinity Purification
- ClonePolyclonal
- Isotypenot specified
- Antigen antibody binding interactionRabbit anti Integrin antibody beta 3 (platelet glycoprotein IIIa antibody antigen CD61) (ITGB3) Antibody
- Antibody is raised inRabbit
- Antibody s reacts withHuman
- Antibody s reacts with these speciesThis antibody doesn't cross react with other species
- Labelunlabeled
- Antibody s specificityNo Data Available
- ApplicationImmunohistochemistry-Paraffin
- Antibody s suited forAntibody can be used for immunohistochemistry on formalin-fixed, paraffin-embedded tissues (2-4 µg/ml)._x000B_Optimal concentration should be evaluated by serial dilutions.
- StorageLong term: -70ºC; Short term: +4ºC
- Relevant referencesno information yet
- Protein numbersee ncbi
- WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
- Antibody s link
- Alternative to gene target
- [ "integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)", "BDPLT16 and BDPLT2 and CD61 and GP3A and GPIIIa and GT", "ITGB3 and IDBG-547297 and ENSG00000259207 and 3690", "cell adhesion molecule binding", "nuclei" ]
- Gene targetIntegrin beta 3 platelet glycoprotein IIIa CD61 ITGB3
- Identity:HGNC:6156
- Gene:ITGB3
- Long gene name:integrin subunit beta 3
- Synonyms gene name:integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
- Synonyms:CD61GPIIIa
- Discovery year:1988-06-09
- Entrez gene record:3690
- Pubmed identification:2454952
- RefSeq identity:NM_000212
- Classification:CD molecules, Integrin beta subunits
- VEGA ID:OTTHUMG00000171956
- Gene symbolITGB3
- HostRabbit, Rabbits
- isotype filter
- not specified
- Short nameRabbit anti Integrin antibody beta 3 (platelet glycoprotein IIIa antibody antigen CD61) (ITGB3)
- label filter
- unlabeled
- technique filter
- Antibody
- antigen
- Rabbit
- anti
- TechniqueAntibody, antigen, Rabbit, anti, antibody to, antibodies against human proteins, antibodies for, antigenes
- Alternative techniqueantibodies, antigenes, rabbit-anti
Gene info
Locus Specific Databases:LRG_481