Mouse anti Caspase-7

• Catalog number
  X1267M
• Price
  Please ask
• Size
  100 μg

• Category
  Primary Antibodies
• Long description
  Caspases are key effectors of programmed cell death. Caspase-7 along with caspase 3 and 6 form the group of effector caspases that are responsible for the cleavage of multiple substrates including the cytokeratins, PARP, alpha fodrin, NuMA and others. Caspase-7 is a 303 amino acid protein with high similarity to caspase-3. Caspase-7 occurs in three varient forms. Granzyme B activates pro-caspase-7 to a form which can cleave poly(ADP-ribose) polymerase (PARP) to its signature fragment of ~85 kDa. Also, in vivo caspase-7 appears to be a better substrate for granzyme B than caspase-3. Pro-caspase-7 has been shown to exist as dimers or high order oligomers. Caspase-7 may be an important intracellular effector of granzyme B-mediated apoptosis and cytotoxic T-lymophocyte-induced cell killing in vivo.
• Antibody come from
  n/a
• Other description
  Protein A/G Chromatography
• Clone
  MCH3-5
• Antigen antibody binding interaction
  Mouse anti Caspase-7 Antibody
• Antibody is raised in
  Mouse
• Antibody s reacts with
  Human
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  No Data Available
• Application
  Western Blot
• Antibody s suited for
  Optimal concentration should be evaluated by serial dilutions.
• Storage
  -20ºC
• Relevant references
  no information yet
• Protein number
  see ncbi
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus

• Gene target
  Caspase-7  
• Gene symbol
  CASP7, MZB1
• Short name
  Mouse anti Caspase-7
• Technique
  Mouse, anti, antibody to, mouses
• Host
  mouse
• Isotype
  IgG
• Label
  unlabeled
• Species
  Mouse, Mouses
• Alternative name
  Mouse antibody to caspase-7
• Alternative technique
  murine, antibodies

Gene info

• Identity
  HGNC:1508
• Gene
  CASP7
• Long gene name
  caspase 7
• Synonyms gene name
  • caspase 7, apoptosis-related cysteine protease
  • caspase 7, apoptosis-related cysteine peptidase
• Synonyms
  • MCH3
  • CMH-1
  • ICE-LAP3
• GenBank acession
  • U37448
• Locus
  10q25.3
• Discovery year
  1996-07-22
• Entrez gene record
  840
• Pubmed identfication
  • 8521391
  • 8576161
• RefSeq identity
  • NM_033338
• Classification
  • Caspases
• VEGA ID
  OTTHUMG00000019076

Gene info

• Identity
  HGNC:30125
• Gene
  MZB1
• Long gene name
  marginal zone B and B1 cell specific protein
• Synonyms gene name
  • marginal zone B and B1 cell-specific protein
• Synonyms
  • PACAP
  • MGC29506
  • HSPC190
  • pERp1
  • MEDA-7
• Synonyms name
  • plasma cell-induced ER protein 1
  • proapoptotic caspase adaptor protein
  • mesenteric oestrogen-dependent adipose gene- 7
• GenBank acession
  • AF151024
• Locus
  5q31.2
• Discovery year
  2012-09-19
• Entrez gene record
  51237
• Pubmed identfication
  • 22573353
  • 12573802
  • 11350957
  • 21093319
  • 21688198
• RefSeq identity
  • NM_016459
• VEGA ID
  OTTHUMG00000163390

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

Similar products