TNF-alpha

Alternative names

Tumor necrosis factor, RATTNF, TNF-alpha, Tnfa
Product Type

Recombinant Protein
NCBI

NP_036807
Concentration

1mg/ml (determined by Absorbance at 280nm)
Formulation

Liquid. In Phosphate Buffer Saline (pH7.4) containing 10% glycerol, 1mM DTT
SDSPAGE Comment and Pic

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain {ATGP3736-SDSPAGE.jpg}
Purity

> 90% by SDS - PAGE
Applications

Bioactivity,SDS-PAGE
Antigen Species

Rat
UniProt No

P16599
Gene Category

Hormones & Cytokines
Molecular Weight

19.9kDa (181aa), confirmed by MALDI-TOF
Tag

His-Tag
Expression System

E.coli
Storage and shipping

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Data sheet
Note

This product is available in other size; please contact us for more details
Description

The TNF-alpha is a α- or alpha protein sometimes glycoprotein present in blood.
Gene

Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.

Gene target

TNF-alpha
Gene symbol

TNF, TNFRSF1A, TNFRSF1B, LTBR
Short name

TNF-alpha
Alternative name

tumor necrosis factor-a
Alternative to gene target

tumor necrosis factor, DIF and TNF-alpha and TNFA and TNFSF2, TNF and IDBG-300259 and ENSG00000232810 and 7124, transcription regulatory region DNA binding, Extracellular, Tnf and IDBG-177358 and ENSMUSG00000024401 and 21926, TNF and IDBG-634161 and ENSBTAG00000025471 and 280943

Identity

HGNC:11916
Gene

TNFRSF1A
Long gene name

TNF receptor superfamily member 1A
Synonyms gene
- TNFR1
Synonyms gene name
- tumor necrosis factor receptor superfamily, member 1A
Synonyms
- TNF-R
- TNFAR
- TNFR60
- TNF-R-I
- CD120a
- TNF-R55
GenBank acession
- M75866
Locus

12p13.31
Discovery year

1991-01-15
Entrez gene record

7132
Pubmed identfication
- 1655358
- 2158863
RefSeq identity
- NM_001065
Classification
- Tumor necrosis factor receptor superfamily
- CD molecules
VEGA ID

OTTHUMG00000168267
Locus Specific Databases
- INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations
- LRG_193

Identity

HGNC:11917
Gene

TNFRSF1B
Long gene name

TNF receptor superfamily member 1B
Synonyms gene
- TNFR2
Synonyms gene name
- tumor necrosis factor receptor superfamily, member 1B
Synonyms
- TNFBR
- TNFR80
- TNF-R75
- TNF-R-II
- p75
- CD120b
GenBank acession
- M32315
Locus

1p36.22
Discovery year

1991-01-15
Entrez gene record

7133
Pubmed identfication
- 2158863
- 8702885
RefSeq identity
- NM_001066
Classification
- CD molecules
- MicroRNA protein coding host genes
- Tumor necrosis factor receptor superfamily
VEGA ID

OTTHUMG00000001829