TNF ALPHA Protein

Storage

For short term storage TNF ALPHA Protein may be kep at +4 deg. C. For long term storage keep the aliquoted vials frozen at -20 degrees Celsius.
Tips

Due to handling and transportation, small amounts of the TNF ALPHA Protein may get caught on the walls or seal of the vials. Prior to use briefly rund the vial(s) through a centrifuge to collect all of the content on the bottom. Avoid freezing and thawing the vials numerous times as such cycles may denaturate the peptide chains and influence the item's performance.
Description

The TNF ALPHA Protein is a α- or alpha protein sometimes glycoprotein present in blood.
Gene

Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.

Gene target

TNF ALPHA Protein
Gene symbol

TNF, TNFRSF1A, SRPRA, TNFRSF1B, CBX5, AGPAT1, DRAP1, SCART1, TUBA3D, TLK2
Short name

TNF ALPHA Protein
Alternative name

TNF ALPHA peptide
Alternative to gene target

tumor necrosis factor, DIF and TNF-alpha and TNFA and TNFSF2, TNF and IDBG-300259 and ENSG00000232810 and 7124, transcription regulatory region DNA binding, Extracellular, Tnf and IDBG-177358 and ENSMUSG00000024401 and 21926, TNF and IDBG-634161 and ENSBTAG00000025471 and 280943

Identity

HGNC:11916
Gene

TNFRSF1A
Long gene name

TNF receptor superfamily member 1A
Synonyms gene
- TNFR1
Synonyms gene name
- tumor necrosis factor receptor superfamily, member 1A
Synonyms
- TNF-R
- TNFAR
- TNFR60
- TNF-R-I
- CD120a
- TNF-R55
GenBank acession
- M75866
Locus

12p13.31
Discovery year

1991-01-15
Entrez gene record

7132
Pubmed identfication
- 1655358
- 2158863
RefSeq identity
- NM_001065
Classification
- Tumor necrosis factor receptor superfamily
- CD molecules
VEGA ID

OTTHUMG00000168267
Locus Specific Databases
- INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations
- LRG_193

Identity

HGNC:11917
Gene

TNFRSF1B
Long gene name

TNF receptor superfamily member 1B
Synonyms gene
- TNFR2
Synonyms gene name
- tumor necrosis factor receptor superfamily, member 1B
Synonyms
- TNFBR
- TNFR80
- TNF-R75
- TNF-R-II
- p75
- CD120b
GenBank acession
- M32315
Locus

1p36.22
Discovery year

1991-01-15
Entrez gene record

7133
Pubmed identfication
- 2158863
- 8702885
RefSeq identity
- NM_001066
Classification
- CD molecules
- MicroRNA protein coding host genes
- Tumor necrosis factor receptor superfamily
VEGA ID

OTTHUMG00000001829

Identity

HGNC:1555
Gene

CBX5
Long gene name

chromobox 5
Synonyms gene name
- chromobox homolog 5 (Drosophila HP1 alpha)
- chromobox homolog 5 (HP1 alpha homolog, Drosophila)
- chromobox homolog 5
Synonyms
Synonyms name
- HP1 alpha homolog (Drosophila)
GenBank acession
- U26311
Locus

12q13.13
Discovery year

1999-10-12
Entrez gene record

23468
Pubmed identfication
- 8663349
RefSeq identity
- NM_012117
Classification
- Chromobox family
- MicroRNA protein coding host genes
VEGA ID

OTTHUMG00000169700

Identity

HGNC:324
Gene

AGPAT1
Long gene name

1-acylglycerol-3-phosphate O-acyltransferase 1
Synonyms gene name
- 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
Synonyms
- LPAAT-alpha
Synonyms name
- lysophosphatidic acid acyltransferase, alpha
GenBank acession
- U56417
Locus

6p21.32
Discovery year

1999-12-07
Entrez gene record

10554
Pubmed identfication
- 9461603
- 9291118
RefSeq identity
- NM_006411
Classification
- MicroRNA protein coding host genes
- 1-acylglycerol-3-phosphate O-acyltransferases
VEGA ID

OTTHUMG00000031210