TP63 Antibody

• Catalog number
  F43397-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  TP63
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000
• Notes
  Titration of the TP63 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This TP63 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q9H3D4
• Purity
  Antigen affinity
• Description
  This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.
• Immunogen
  A portion of amino acids 651-680 from the human protein was used as the immunogen for this TP63 antibody.
• Storage
  Aliquot the TP63 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TP63  
• Gene symbol
  TP63
• Short name
  Anti-TP63
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to TP63
• Alternative technique
  antibodies
• Alternative to gene target
  tumor protein p63, AIS and B(p51A) and B(p51B) and EEC3 and KET and LMS and NBP and OFC8 and p40 and p51 and p53CP and p63 and p73H and p73L and RHS and SHFM4 and TP53CP and TP53L and TP73L, TP63 and IDBG-69487 and ENSG00000073282 and 8626, WW domain binding, nuclei, Trp63 and IDBG-150133 and ENSMUSG00000022510 and 22061, TP63 and IDBG-634533 and ENSBTAG00000015460 and 615335

Gene info

• Identity
  HGNC:15979
• Gene
  TP63
• Long gene name
  tumor protein p63
• Synonyms gene
  • TP73L
  • TP53L
  • TP53CP
• Synonyms gene name
  • tumor protein p73-like
  • tumor protein p53-like
  • tumor protein p53-competing protein
• Synonyms
  • p51
  • SHFM4
  • EEC3
  • p63
  • p73L
  • OFC8
  • KET
  • p73H
  • NBP
  • p53CP
• GenBank acession
  • AB010153
• Locus
  3q28
• Discovery year
  2002-04-18
• Entrez gene record
  8626
• Pubmed identfication
  • 9774969
  • 9662378
  • 11181441
  • 11181451
• RefSeq identity
  • NM_003722
• Classification
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000156313
• Locus Specific Databases
  • Global Variome shared LOVD
  • LRG_428

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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