TAB1 Antibody
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Catalog numberR32237
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PricePlease ask
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Size0.1mg
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CategoryAntibody
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Concentration0.5mg/ml if reconstituted with 0.2ml sterile DI water
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FormAntigen affinity purified
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ConjugationUnconjugated
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ClonePolyclonal antibody
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Recognised antigenTAB1
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Host animalRabbit (Oryctolagus cuniculus)
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ClonalityPolyclonal (rabbit origin)
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Species reactivityHuman (Homo sapiens), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
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Tested applicationsWB
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Recommended dilutionsWestern blot: 0.1-0.5ug/ml
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NotesOptimal dilution of the TAB1 antibody should be determined by the researcher.
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Intented useThis TAB1 antibodyis to be used only for research purposes and not for diagnostics..
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UniprotQ15750
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PurityAntigen affinity
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DescriptionMitogen-activated protein kinase kinase kinase 7-interacting protein 1, also called TAB1, is an enzyme that in humans is encoded by the MAP3K7IP1 gene. It is mapped to 22q13.1. The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways. This protein can interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. TAB1 also can activate the kinase activity of TAK1 by direct interaction, and it may be an important signaling intermediate between TGFB receptors and TAK1. What's more, TAB1 plays an important role in skin homeostasis, wound repair, and oncogenesis.
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ImmunogenAmino acids NFVAQRLSAELLLGQLNAEHAEADVRRVLLQ of human TAB1 were used as the immunogen for the TAB1 antibody.
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StorageAfter reconstitution, the TAB1 antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
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PropertiesIf you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolTAB1
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Short nameAnti-TAB1
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeRabbit IgG
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Alternative nameAntibodies to TAB1
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Alternative techniqueantibodies
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Alternative to gene targetTGF-beta activated kinase 1/MAP3K7 binding protein 1, 3\'-Tab1 and MAP3K7IP1, TAB1 and IDBG-8281 and ENSG00000100324 and 10454, mitogen-activated protein kinase p38 binding, nuclei, Tab1 and IDBG-163423 and ENSMUSG00000022414 and 66513, MAP3K7IP1 and IDBG-641725 and ENSBTAG00000019828 and 519958
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Gene info
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Identity
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Gene
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Long gene nameTGF-beta activated kinase 1 (MAP3K7) binding protein 1
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Synonyms gene
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Synonyms gene name
- mitogen-activated protein kinase kinase kinase 7 interacting protein 1
- TGF-beta activated kinase 1/MAP3K7 binding protein 1
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Synonyms name
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GenBank acession
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Locus
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Discovery year2002-02-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data