MAVS Antibody

• Catalog number
  F43253-0.4ML
• Price
  Please ask
• Size
  0.4 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  MAVS
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000
• Notes
  Titration of the MAVS antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This MAVS antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q7Z434
• Purity
  Antigen affinity
• Description
  Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 or by the cytoplasmic RNA helicases MDA5 and RIGI. These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA and IKKB which activate NFKB, or TBK1 and IKKE (IKBKE; MIM 605048), which activate IRF3. Activated IRF3 and NFKB induce transcription of IFNB. For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF. For RIGI, the intermediary protein is mitochondria-bound IPS1.
• Immunogen
  A portion of amino acids 477-505 from the human protein was used as the immunogen for this MAVS antibody.
• Storage
  Aliquot the MAVS antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MAVS  
• Gene symbol
  MAVS
• Short name
  Anti-MAVS
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to MAVS
• Alternative technique
  antibodies
• Alternative to gene target
  mitochondrial antiviral signaling protein, MAVS and IDBG-49080 and ENSG00000088888 and 57506, CARD domain binding, Plasma membranes, Mavs and IDBG-207066 and ENSMUSG00000037523 and 228607, BT.45349 and IDBG-640031 and ENSBTAG00000013545 and 618508

Gene info

• Identity
  HGNC:29233
• Gene
  MAVS
• Long gene name
  mitochondrial antiviral signaling protein
• Synonyms
  • VISA
  • KIAA1271
  • IPS-1
  • Cardif
• Synonyms name
  • virus-induced signaling adaptor
  • IFN-B promoter stimulator 1
  • CARD adaptor inducing IFN-beta
• GenBank acession
  • DQ174270
• Locus
  20p13
• Discovery year
  2009-04-01
• Entrez gene record
  57506
• Pubmed identfication
  • 16125763
  • 16153868
• RefSeq identity
  • NM_020746
• Classification
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000031765

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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