Mavs Antibody (Ips-1)

• Catalog number
  F47745-0.08ML
• Price
  Please ask
• Size
  0.08 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  Mavs (Ips-1)
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000
• Notes
  Titration of the Ips-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This Ips-1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q8VCF0
• Purity
  Antigen affinity
• Description
  Required for innate immune defense against viruses. Acts downstream of DDX58 and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis (By similarity).
• Immunogen
  A portion of amino acids 1-30 from the mouse protein was used as the immunogen for this Ips-1 antibody.
• Storage
  Aliquot the Ips-1 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Mavs   Ips-1  
• Gene symbol
  MAVS
• Short name
  Anti-Mavs (Ips-1)
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to Mavs (Ips-1)
• Alternative technique
  antibodies
• Alternative to gene target
  mitochondrial antiviral signaling protein, MAVS and IDBG-49080 and ENSG00000088888 and 57506, CARD domain binding, Plasma membranes, Mavs and IDBG-207066 and ENSMUSG00000037523 and 228607, BT.45349 and IDBG-640031 and ENSBTAG00000013545 and 618508

Gene info

• Identity
  HGNC:29233
• Gene
  MAVS
• Long gene name
  mitochondrial antiviral signaling protein
• Synonyms
  • VISA
  • KIAA1271
  • IPS-1
  • Cardif
• Synonyms name
  • virus-induced signaling adaptor
  • IFN-B promoter stimulator 1
  • CARD adaptor inducing IFN-beta
• GenBank acession
  • DQ174270
• Locus
  20p13
• Discovery year
  2009-04-01
• Entrez gene record
  57506
• Pubmed identfication
  • 16125763
  • 16153868
• RefSeq identity
  • NM_020746
• Classification
  • Caspase recruitment domain containing
• VEGA ID
  OTTHUMG00000031765

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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