LRRK2 Antibody

• Catalog number
  F53185-0.4ML
• Price
  Please ask
• Size
  0.4 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  LRRK2
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000
• Notes
  Titration of the LRRK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This LRRK2 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q5S007
• Purity
  Antigen affinity
• Description
  Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Phosphorylates PRDX3. May also have GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.
• Immunogen
  This LRRK2 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 2171-2207 amino acids from the C-terminal region of human LRRK2.
• Storage
  Aliquot the LRRK2 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  LRRK2  
• Gene symbol
  LRRK2-DT, LRRK2
• Short name
  Anti-LRRK2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to LRRK2
• Alternative technique
  antibodies
• Alternative to gene target
  leucine-rich repeat kinase 2, LRRK2 and IDBG-27257 and ENSG00000188906 and 120892, transferase activity, Extracellular, Lrrk2 and IDBG-175625 and ENSMUSG00000036273 and 66725, LRRK2 and IDBG-633456 and ENSBTAG00000016260 and 535652

Gene info

• Identity
  HGNC:40848
• Gene
  LRRK2-DT
• Long gene name
  LRRK2 divergent transcript
• Locus
  12q12
• Discovery year
  2019-08-16
• Entrez gene record
  107984474
• Classification
  • Divergent transcripts

Gene info

• Identity
  HGNC:18618
• Gene
  LRRK2
• Long gene name
  leucine rich repeat kinase 2
• Synonyms gene
  • PARK8
• Synonyms gene name
  • Parkinson disease (autosomal dominant) 8
• Synonyms
  • ROCO2
  • DKFZp434H2111
  • FLJ45829
  • RIPK7
• Synonyms name
  • dardarin
• GenBank acession
  • AK026776
• Locus
  12q12
• Discovery year
  2004-10-22
• Entrez gene record
  120892
• Pubmed identfication
  • 15541308
• RefSeq identity
  • NM_198578
• Classification
  • Armadillo like helical domain containing
  • ROCO family
• VEGA ID
  OTTHUMG00000059742
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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