LRRK2 Antibody

• Catalog number
  PB9281
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  LRRK2
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human, rat
• Analyses
  WB
• Immunogen
  E.coli-derived human LRRK2 recombinant protein (Position: E10-L350). Human LRRK2 shares 82% amino acid (aa) sequence identity with mouse LRRK2.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the LRRK2 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The LRRK2 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  Leucine-rich repeat kinase 2 (LRRK2), also known as dardarin, is anenzyme that in humans is encoded by the PARK8 gene. It is a member of the leucine-rich repeat kinase family. This gene is mapped to 12q12. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Expression of mutant LRRK2 induced apoptotic cell death in neuroblastoma cells and in mouse cortical neurons. It has been determined that LRRK2 possesses mixed-lineage kinase activity, and LRRK2 also showed autophosphorylation activity. What’s more, LRRK2 has an affinity for lipids or lipid-associated proteins and may play a role in the biogenesis or regulation of membranous intracellular structures in the brain. It is also an IFNG target gene that may be involved in signaling pathways relevant to Crohn disease.
• Related articles
  1. Biskup, S., Moore, D. J., Celsi, F., Higashi, S. West, A. B., Andrabi, S. A., Kurkinen, K., Yu, S.-W., Savitt, J. M., Waldvogel, H. J., Faull, R. L. M., Emson, P. C., Torp, R., Ottersen, O. P., Dawson, T. M., Dawson, V. L. Localization of LRRK2 to membranous and vesicular structures in mammalian brain. Ann. Neurol. 60: 557-569, 2006. 2. Paisán-Ruíz C, Jain S, Evans EW, Gilks WP, Simón J, van der Brug M, López de Munain A, Aparicio S, Gil AM, Khan N, Johnson J, Martinez JR, Nicholl D, Carrera IM, Pena AS, de Silva R, Lees A, Martí-Massó JF, Pérez-Tur J, Wood NW, Singleton AB (November 2004). "Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease". Neuron 44 (4): 595–600. 3. West, A. B., Moore, D. J., Biskup, S., Bugayenko, A., Smith, W. W., Ross, C. A., Dawson, V. L., Dawson, T. M. Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Proc. Nat. Acad. Sci. 102: 16842-16847, 2005.
• Gene Name
  LRRK2
• Protein Name
  Leucine-rich repeat serine/threonine-protein kinase 2
• Gene Full Name
  leucine-rich repeat kinase 2
• Synonyms
  augmented in rheumatoid arthritis 17 antibody|AURA17 antibody|Dardarin antibody|Leucine rich repeat kinase 2 antibody|leucine rich repeat serine threonine protein kinase 2 antibody|Leucine-rich repeat serine/threonine-protein kinase 2 antibody|LRRK 2 antibody|LRRK2 antibody|LRRK2_HUMAN antibody|PARK 8 antibody|PARK8 antibody|RIPK7 antibody|ROCO 2 antibody|ROCO2 antibody
• Uniprot ID
  Q5S007
• Entrez GeneID
  120892
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  LRRK2  
• Gene symbol
  LRRK2-DT, LRRK2
• Short name
  LRRK2 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  leucine-rich repeat kinase 2 (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  leucine-rich repeat kinase 2, LRRK2 and IDBG-27257 and ENSG00000188906 and 120892, transferase activity, Extracellular, Lrrk2 and IDBG-175625 and ENSMUSG00000036273 and 66725, LRRK2 and IDBG-633456 and ENSBTAG00000016260 and 535652

Gene info

• Identity
  HGNC:40848
• Gene
  LRRK2-DT
• Long gene name
  LRRK2 divergent transcript
• Locus
  12q12
• Discovery year
  2019-08-16
• Entrez gene record
  107984474
• Classification
  • Divergent transcripts

Gene info

• Identity
  HGNC:18618
• Gene
  LRRK2
• Long gene name
  leucine rich repeat kinase 2
• Synonyms gene
  • PARK8
• Synonyms gene name
  • Parkinson disease (autosomal dominant) 8
• Synonyms
  • ROCO2
  • DKFZp434H2111
  • FLJ45829
  • RIPK7
• Synonyms name
  • dardarin
• GenBank acession
  • AK026776
• Locus
  12q12
• Discovery year
  2004-10-22
• Entrez gene record
  120892
• Pubmed identfication
  • 15541308
• RefSeq identity
  • NM_198578
• Classification
  • Armadillo like helical domain containing
  • ROCO family
• VEGA ID
  OTTHUMG00000059742
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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