ITPR3 Antibody

• Catalog number
  R32229
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  ITPR3
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P
• Recommended dilutions
  Western blot: 0.1-0.5ug/ml,IHC (Paraffin): 0.5-1ug/ml
• Notes
  Optimal dilution of the ITPR3 antibody should be determined by the researcher.
• Intented use
  This ITPR3 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q14573
• Purity
  Antigen affinity
• Description
  ITPR3 encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. ITP3 channels serve an important role in the taste transduction pathway of sweet, bitter and umami tastes the gustatory system. ITP3 channels allow the flow of Calcium out of the endoplasmic reticulum in response to IP3. Calcium cations result in the activation of TRPM5 which leads to a depolarisation generating potential and an action potential.
• Immunogen
  Amino acids QYWKAKQTKQDKEKIADVVLLQKLQH of human ITPR3 were used as the immunogen for the ITPR3 antibody.
• Storage
  After reconstitution, the ITPR3 antibody may be kept for up to one month refrigerated at +4 degrees C.For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ITPR3  
• Gene symbol
  ITPR3
• Short name
  Anti-ITPR3
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to ITPR3
• Alternative technique
  antibodies
• Alternative to gene target
  inositol 1,4,5-trisphosphate receptor, type 3, IP3R and IP3R3, ITPR3 and IDBG-82972 and ENSG00000096433 and 3710, inositol 1, nuclei, Itpr3 and IDBG-156294 and ENSMUSG00000042644 and 16440, ITPR3 and IDBG-629118 and ENSBTAG00000013245 and 281879

Gene info

• Identity
  HGNC:6182
• Gene
  ITPR3
• Long gene name
  inositol 1,4,5-trisphosphate receptor type 3
• Synonyms gene name
  • inositol 1,4,5-triphosphate receptor, type 3
  • inositol 1,4,5-trisphosphate receptor, type 3
• Synonyms
  • IP3R3
• GenBank acession
  • D26351
• Locus
  6p21.31
• Discovery year
  1991-06-05
• Entrez gene record
  3710
• Pubmed identfication
  • 8081734
  • 8288584
• RefSeq identity
  • NM_002224
• Classification
  • Inositol 1,4,5-triphosphate receptors
  • Protein phosphatase 1 regulatory subunits
• VEGA ID
  OTTHUMG00000014532

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Similar products