COPS7B Antibody / CSN7b
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Catalog numberF53955-0.2ML
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PricePlease ask
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Size0.2 ml
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CategoryAntibody
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ConcentrationIn 1X PBS, pH 7.4, with 0.09% sodium azide
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FormAntigen affinity purified
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ConjugationUnconjugated
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ClonePolyclonal antibody
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Recognised antigenCOPS7B / CSN7b
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Host animalRabbit (Oryctolagus cuniculus)
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ClonalityPolyclonal (rabbit origin)
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Species reactivityHuman (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
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Tested applicationsWB
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Recommended dilutionsWestern blot: 1:500-1:1000
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Intented useThis COPS7B antibodyis to be used only for research purposes and not for diagnostics..
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Gene ID64708
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UniprotQ9H9Q2
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PurityAntigen affinity
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DescriptionCOP9 signalosome complex subunit 7b is a component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
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ImmunogenA portion of amino acids 223-257 from the human protein was used as the immunogen for the COPS7B antibody.
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StorageAliquot the COPS7B antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
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PropertiesIf you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolCOPS7B
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Short nameAnti- COPS7B / CSN7b
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeRabbit Ig
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Alternative nameAntibodies to COPS7B / CSN7b
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene nameCOP9 signalosome subunit 7B
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Synonyms gene name
- COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 7B
- COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis)
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-10-03
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- COP9 signalosome
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data