COPS7B Antibody / CSN7b

• Catalog number
  F53955-0.05ML
• Price
  Please ask
• Size
  0.05 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  COPS7B / CSN7b
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 1:500-1:1000
• Intented use
  This COPS7B antibodyis to be used only for research purposes and not for diagnostics..
• Gene ID
  64708
• Uniprot
  Q9H9Q2
• Purity
  Antigen affinity
• Description
  COP9 signalosome complex subunit 7b is a component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
• Immunogen
  A portion of amino acids 223-257 from the human protein was used as the immunogen for the COPS7B antibody.
• Storage
  Aliquot the COPS7B antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  COPS7B   CSN7b  
• Gene symbol
  COPS7B
• Short name
  Anti- COPS7B / CSN7b
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to COPS7B / CSN7b
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:16760
• Gene
  COPS7B
• Long gene name
  COP9 signalosome subunit 7B
• Synonyms gene name
  • COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 7B
  • COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis)
• Synonyms
  • CSN7B
• GenBank acession
  • AK022674
• Locus
  2q37.1
• Discovery year
  2001-10-03
• Entrez gene record
  64708
• Pubmed identfication
  • 9707402
• RefSeq identity
  • NM_022730
• Classification
  • COP9 signalosome
• VEGA ID
  OTTHUMG00000133228

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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