Recombinant Human TNF-Related Apoptosis Inducing Ligand/Apo2L (114-281), Active

• Catalog number
  MBS147041
• Price
  Please ask
• Size
  0.002 mg

• Products_type
  Active Protein
• Products_short_name
  [TNF-Related Apoptosis Inducing Ligand/Apo2L]
• Products_name_syn
  [Tumor necrosis factor ligand superfamily member 10; TNF-related apoptosis-inducing ligand; Protein TRAIL; Apo-2 ligand; Apo-2L; CD253 antigen; TL2; APO2L; TNFSF10; TRAIL Human (114-281 a.a.), Active; TRAIL/APO 2 Ligand (114-281 a.a.) Human Recombinant, Active]
• Other_names
  [Tumor necrosis factor ligand superfamily member 10; Tumor necrosis factor ligand superfamily member 10; tumor necrosis factor ligand superfamily member 10; TNF superfamily member 10; Apo-2 ligand; Apo-2L; TNF-related apoptosis-inducing ligand; Protein TRAIL; CD_antigen: CD253]
• Products_gene_name
  [TRAIL]
• Other_gene_names
  [TNFSF10; TNFSF10; TL2; APO2L; CD253; TRAIL; Apo-2L; TNLG6A; APO2L; TRAIL; Apo-2L; Protein TRAIL]
• Purity
  Greater than 95.0% as determined by SDS-PAGE
• Form
  Sterile filtered colorless liquidProtein solution (1mg/ml) containing 20mM Tris-HCl pH-7.5, 300mM NaCl, 0.1mM DTT & 10% glycerol
• Storage_stability
  Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at-20 degree C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles
• Description
  This 1 is suited for programmed cell-death studies. FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants
• Gene
  Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.

• Gene target
  TNF-Related   Ligand/Apo2L   114-281   Active  
• Gene symbol
  TNF, TNFRSF1A, TNFRSF1B, LTBR, REXO2, CDK5RAP3, OR4H6P
• Short name
  Recombinant TNF- Apoptosis Ligand/Apo2L (114-281), Active
• Technique
  Recombinant, apoptosis, apoptosis pathway, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. MyBioSource advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Host
  Escherichia Coli
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens tumor necrosis factor-Related programmed cellular destruction Inducing Ligand/Apo2L (114-281), functionnal
• Alternative technique
  rec, celldeath
• Alternative to gene target
  tumor necrosis factor, DIF and TNF-alpha and TNFA and TNFSF2, TNF and IDBG-300259 and ENSG00000232810 and 7124, transcription regulatory region DNA binding, Extracellular, Tnf and IDBG-177358 and ENSMUSG00000024401 and 21926, TNF and IDBG-634161 and ENSBTAG00000025471 and 280943

Gene info

• Identity
  HGNC:11892
• Gene
  TNF
• Long gene name
  tumor necrosis factor
• Synonyms gene
  • TNFA
• Synonyms gene name
  • tumor necrosis factor (TNF superfamily, member 2)
• Synonyms
  • TNFSF2
  • DIF
  • TNF-alpha
• Synonyms name
  • TNF superfamily, member 2
• GenBank acession
  • X02910
• Locus
  6p21.33
• Discovery year
  1986-01-01
• Entrez gene record
  7124
• Pubmed identfication
  • 2413547
  • 6392892
• Classification
  • Tumor necrosis factor superfamily
• VEGA ID
  OTTHUMG00000031194

Gene info

• Identity
  HGNC:11916
• Gene
  TNFRSF1A
• Long gene name
  TNF receptor superfamily member 1A
• Synonyms gene
  • TNFR1
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 1A
• Synonyms
  • TNF-R
  • TNFAR
  • TNFR60
  • TNF-R-I
  • CD120a
  • TNF-R55
• GenBank acession
  • M75866
• Locus
  12p13.31
• Discovery year
  1991-01-15
• Entrez gene record
  7132
• Pubmed identfication
  • 1655358
  • 2158863
• RefSeq identity
  • NM_001065
• Classification
  • Tumor necrosis factor receptor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000168267
• Locus Specific Databases
  • INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations
  • LRG_193

Gene info

• Identity
  HGNC:11917
• Gene
  TNFRSF1B
• Long gene name
  TNF receptor superfamily member 1B
• Synonyms gene
  • TNFR2
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 1B
• Synonyms
  • TNFBR
  • TNFR80
  • TNF-R75
  • TNF-R-II
  • p75
  • CD120b
• GenBank acession
  • M32315
• Locus
  1p36.22
• Discovery year
  1991-01-15
• Entrez gene record
  7133
• Pubmed identfication
  • 2158863
  • 8702885
• RefSeq identity
  • NM_001066
• Classification
  • CD molecules
  • MicroRNA protein coding host genes
  • Tumor necrosis factor receptor superfamily
• VEGA ID
  OTTHUMG00000001829

Gene info

• Identity
  HGNC:6718
• Gene
  LTBR
• Long gene name
  lymphotoxin beta receptor
• Synonyms gene
  • D12S370
• Synonyms
  • TNFCR
  • TNFR-RP
  • TNFR2-RP
  • TNF-R-III
  • TNFRSF3
• Synonyms name
  • TNFR superfamily, member 3
• GenBank acession
  • L04270
• Locus
  12p13.31
• Discovery year
  1996-03-12
• Entrez gene record
  4055
• Pubmed identfication
  • 8171323
  • 8486360
• Classification
  • Tumor necrosis factor receptor superfamily
• VEGA ID
  OTTHUMG00000168356

Gene info

• Identity
  HGNC:17851
• Gene
  REXO2
• Long gene name
  RNA exonuclease 2
• Synonyms gene name
  • REX2, RNA exonuclease 2 homolog (S. cerevisiae)
• Synonyms
  • DKFZP566E144
  • SFN
  • CGI-114
• GenBank acession
  • AF151872
• Locus
  11q23.2
• Discovery year
  2005-08-19
• Entrez gene record
  25996
• Pubmed identfication
  • 10851236
  • 10810093
  • 23741365
• RefSeq identity
  • NM_015523
• Classification
  • Exonucleases
• VEGA ID
  OTTHUMG00000168271

Gene info

• Identity
  HGNC:18673
• Gene
  CDK5RAP3
• Long gene name
  CDK5 regulatory subunit associated protein 3
• Synonyms
  • MST016
  • FLJ13660
  • C53
  • IC53
  • HSF-27
  • OK/SW-cl.114
  • LZAP
• Synonyms name
  • ischemic heart CDK5 activator-binding protein C53
  • LXXLL/leucine-zipper-containing ARFbinding protein
• GenBank acession
  • AF110322
• Locus
  17q21.32
• Discovery year
  2002-07-22
• Entrez gene record
  80279
• Pubmed identfication
  • 10721722
• RefSeq identity
  • NM_176096
• VEGA ID
  OTTHUMG00000178682

Gene info

• Identity
  HGNC:8312
• Gene
  OR4H6P
• Long gene name
  olfactory receptor family 4 subfamily H member 6 pseudogene
• Synonyms gene
  • OR4H9P
  • OR4H10P
  • OR4H5P
  • OR4H11P
  • OR4H5
  • OR4H7
  • OR4H7P
  • OR4H2P
  • OR4H3P
  • OR4H11
  • OR4H2
  • OR4H3
  • OR4H1P
  • OR4H4P
  • OR4H10
  • OR4H4
  • OR4H8P
  • OR4H8
• Synonyms gene name
  • olfactory receptor, family 4, subfamily H, member 8 pseudogene
  • olfactory receptor, family 4, subfamily H, member 6 pseudogene
• Synonyms
  • OR15-71
  • OR4H6
  • OR15-82
  • OR4H9
  • OR5-39
  • OR5-84
  • OR4-114
  • OR4-115
  • OR4-119
  • OR15-69
  • OR15-80
  • OR15-81
  • OR14-58
• GenBank acession
  • U86230
• Locus
  15q11.2
• Discovery year
  1999-11-25
• Entrez gene record
  26322
• Pubmed identfication
  • 9500546
• Classification
  • Olfactory receptors, family 4
• VEGA ID
  OTTHUMG00000172787

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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