Active Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL)

• Catalog number
  APA139Hu01
• Price
  Please ask
• Size
  200ug

• Source
  NA
• Predicted Molecular Mass KD
  19.6kDa
• Accurate Molecular Mass KD
  19kDa
• Organism species
  Homo sapiens (Human)
• Item Name
  Tumor Necrosis Factor Related Apoptosis Inducing Ligand
• Alternative Names
  CD253; TNFSF10; APO2L; Apo2-L; TL2; TRAIL; Tumor Necrosis Factor Ligand Superfamily Member 10; Apo-2 Ligand
• Research Area
  Apoptosis;Tumor immunity;
• Buffer Formulation
  20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Traits
  Liquid
• Isoelectric Point
  8.6
• Purity
  > 95%
• Protein length
  Val114~Gly281
• Tag
  N-terminal His Tag
• Expression System
  NA
• Application
  Cell culture; Activity Assays.
• Manual link
• Description
  This 1 is suited for programmed cell-death studies. Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.

• Gene target
  Active   Tumor   Necrosis   Factor   Related   Ligand   TRAIL  
• Gene symbol
  TNFSF10, TNFRSF10B
• Short name
  Active Tumor Necrosis Factor Apoptosis Ligand (TRAIL)
• Technique
  apoptosis, apoptosis pathway
• Host
  NA
• Species
  Homo sapiens (Human)
• Alternative name
  functionnal Tumor Necrosis Factor Related programmed cellular destruction Inducing Ligand (TRAIL)
• Alternative technique
  celldeath
• Tissue
  tumor

Gene info

• Identity
  HGNC:11925
• Gene
  TNFSF10
• Long gene name
  TNF superfamily member 10
• Synonyms gene name
  • tumor necrosis factor (ligand) superfamily, member 10
• Synonyms
  • TRAIL
  • Apo-2L
  • TL2
  • CD253
• GenBank acession
  • U37518
• Locus
  3q26
• Discovery year
  1998-12-04
• Pubmed identfication
  • 8777713
  • 8663110
• Classification
  • CD molecules
  • Tumor necrosis factor superfamily
• VEGA ID
  OTTHUMG00000156917

Gene info

• Identity
  HGNC:11905
• Gene
  TNFRSF10B
• Long gene name
  TNF receptor superfamily member 10b
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 10b
• Synonyms
  • DR5
  • KILLER
  • TRICK2A
  • TRAIL-R2
  • TRICKB
  • CD262
  • TRAILR2
• GenBank acession
  • AF012628
• Locus
  8p21.3
• Discovery year
  1998-12-04
• Entrez gene record
  8795
• Pubmed identfication
  • 9285725
  • 9311998
• RefSeq identity
  • NM_147187
• Classification
  • Tumor necrosis factor receptor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000097826

MeSH Data

• Name
  Tumor Stem Cell Assay
• Concept
  Scope note: A cytologic technique for measuring the functional capacity of tumor stem cells by assaying their activity. It is used primarily for the in vitro testing of antineoplastic agents.
• Tree numbers
  • E01.370.225.500.383.910
  • E01.370.225.500.388.930
  • E05.200.500.383.910
  • E05.200.500.388.930
  • E05.242.383.910
  • E05.242.417.500
  • E05.337.550.200.800
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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