Recombinant Human soluble CD40 Ligand (rHu sCD40L)

Products_type

Active Protein
Products_short_name

[sCD40Ligand(TRAP]
Products_name_syn

[human sCD40Ligand(TRAP; rHusCD40L) ; Human soluble CD40 Ligand]
Purity

>95% by SDS-PAGE and HPLC analyses.
Form

Lyophilized from a 0.2mm filtered concentrated solution in PBS, pH 7.0.Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder
Storage_stability

This lyophilized preparation is stable at 2-8 degree C, but should be kept at -20 degree C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 degree C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degree C to -70 degree C. Avoid repeated freeze/thaw cycles.
Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Description

FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
Source

Recombinants or rec. proteins
Group

recombinants

Gene target

soluble CD40 Ligand rHu sCD40L
Gene symbol

CD40
Short name

Recombinant soluble CD40 Ligand (rHu sCD40L)
Technique

Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. MyBioSource advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
Host

E Coli
Species

Human, Humans
Alternative name

Rec. H. sapiens soluble CD40 molecule, tumor necrosis factor receptor superfamily member 5 Ligand (rHu sCD40L)
Alternative technique

rec
Alternative to gene target

CD40 molecule, TNF receptor superfamily member 5, Bp50 and CDW40 and p50 and TNFRSF5, CD40 and IDBG-78904 and ENSG00000101017 and 958, ubiquitin protein ligase binding, Extracellular, Cd40 and IDBG-212533 and ENSMUSG00000017652 and 21939, BT.42498 and IDBG-643036 and ENSBTAG00000020736 and 286849

Identity

HGNC:11919
Gene

CD40
Long gene name

CD40 molecule
Synonyms gene
- TNFRSF5
Synonyms gene name
- tumor necrosis factor receptor superfamily, member 5
- CD40 molecule, TNF receptor superfamily member 5
Synonyms
- p50
- Bp50
GenBank acession
- X60592
Locus

20q13.12
Discovery year

1993-08-27
Entrez gene record

958
Pubmed identfication
- 7687385
- 2998589
RefSeq identity
- NM_001250
Classification
- CD molecules
- Tumor necrosis factor receptor superfamily
VEGA ID

OTTHUMG00000033053
Locus Specific Databases
- CD40base: Mutation registry for CD40 deficiency (previously known as TNFRSF5base)
- LRG_40

Name

CD4 Lymphocyte Count
Concept

Scope note: The number of CD4-POSITIVE T-LYMPHOCYTES per unit volume of BLOOD. Determination requires the use of a fluorescence-activated flow cytometer.
Tree numbers
- E01.370.225.500.195.107.595.500.150
- E01.370.225.625.107.595.500.150
- E05.200.500.195.107.595.500.150
- E05.200.625.107.595.500.150
- E05.242.195.107.595.500.150
Qualifiers

ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data