RABBIT ANTI MUNC-18 (pSer515)

• Catalog number
  MBS221521
• Price
  Please ask
• Size
  0.1 mL

• Products_type
  Antibody
• Products_short_name
  [MUNC-18]
• Other_names
  [syntaxin-binding protein 1; Syntaxin-binding protein 1; syntaxin-binding protein 1; p67; protein unc-18 homolog 1; protein unc-18 homolog A; unc-18-1; unc-18A; syntaxin binding protein 1; N-Sec1; Protein unc-18 homolog 1; Unc18-1; Protein unc-18 homolog A; Unc-18A; p67; rbSec1]
• Products_gene_name
  [MUNC-18]
• Other_gene_names
  [Stxbp1; Stxbp1; Sec1; nSec1; NSEC1A; n-sec1; rbSec1; ANC18HA; Unc18-1; rbSec1A; rbSec1B; Munc18-1; Unc18a; Unc18-1; Unc-18A]
• Clonality
  Polyclonal
• Reactivity
  Bovine (Expected from Sequence), Chicken (Expected from Sequence), Dog (Expected from Sequence), Human (Expected from Sequence), Mouse (Expected from Sequence), Primate (Expected from Sequence), Xenopus (Expected from Sequence)
• Specificity
  This item recognises Munc-18 phosphorylated at serine 515, a 67 kDa member of the STXBP/UNC-18/SEC1 family. It is neural specific, expressed in the brain, spinal cord and at very high levels in axons. Munc-18 is crucial to calcium-dependent neurotransmitter release, facilitating synaptic vesicle docking and fusion. It inhibits the formation of soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) complex by binding syntaxin 1 preventing the other components (synaptobrevin and synaptosomal associated protein of 25 kDa (SNAP-25)) from binding. The function of Munc-18 is regulated by the phosphorylation of serine 515 by protein kinase C. Munc-18 is also involved in the onset of female puberty through its regulation of glutamate release.
• Form
  Purified Purified IgG - liquid
• Storage_stability
  Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of despatch.
• Tested_application
  Western Blot (WB)*
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• About
  Rabbits are used for polyclonal antibody production by MyBioSource. Rabbit antibodies are very stable and can be stored for several days at room temperature. MyBioSource adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
• Latin name
  Oryctolagus cuniculus

• Gene target
  MUNC-18   pSer515  
• Gene symbol
  SNORD114-18, PIRC96, SNORD116-18, IGLV2-18, IGHV1-18, SNORD115-18, ERVW-18, IGKV2D-18, IGKV2-18
• Short name
  RABBIT ANTI MUNC-18 (pSer515)
• Technique
  Rabbit, anti, antibody to
• Host
  Rabbit, Rabbits
• Isotype
  IgG
• Alternative name
  production species: rabbit antibody to MUNC-18 (pSer515)
• Alternative technique
  rabbit-anti, antibodies

Gene info

• Identity
  HGNC:33006
• Gene
  SNORD114-18
• Long gene name
  small nucleolar RNA, C/D box 114-18
• Synonyms
  • 14q(II-18)
• Locus
  14q32.31
• Discovery year
  2006-09-26
• Entrez gene record
  767596
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003211.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:37600
• Gene
  PIRC96
• Long gene name
  piwi-interacting RNA cluster 96
• Locus
  18
• Discovery year
  2009-11-05
• Entrez gene record
  100313800
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:33084
• Gene
  SNORD116-18
• Long gene name
  small nucleolar RNA, C/D box 116-18
• Synonyms
  • HBII-85-18
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033430
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003333
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:5889
• Gene
  IGLV2-18
• Long gene name
  immunoglobulin lambda variable 2-18
• GenBank acession
  • Z73642
• Locus
  22q11.22
• Discovery year
  2000-05-08
• Entrez gene record
  28814
• RefSeq identity
  • NG_000002
• Classification
  • Immunoglobulin lambda locus at 22q11.2
• VEGA ID
  OTTHUMG00000151232

Gene info

• Identity
  HGNC:5549
• Gene
  IGHV1-18
• Long gene name
  immunoglobulin heavy variable 1-18
• GenBank acession
  • M99641
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28468
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152276

Gene info

• Identity
  HGNC:33037
• Gene
  SNORD115-18
• Long gene name
  small nucleolar RNA, C/D box 115-18
• Synonyms
  • HBII-52-18
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033456
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003310.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:49306
• Gene
  ERVW-18
• Long gene name
  endogenous retrovirus group W member 18
• Synonyms gene name
  • endogenous retrovirus group W, member 18
• GenBank acession
  • HG421056
• Locus
  6q24.2
• Discovery year
  2013-10-21

Gene info

• Identity
  HGNC:5794
• Gene
  IGKV2D-18
• Long gene name
  immunoglobulin kappa variable 2D-18 (pseudogene)
• Synonyms gene name
  • immunoglobulin kappa variable 2D-18
  • immunoglobulin kappa variable 2D-18 pseudogene
• GenBank acession
  • X63395
• Locus
  2p11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28888
• RefSeq identity
  • NG_000833
• Classification
  • Immunoglobulin kappa locus at 2p11.2
• VEGA ID
  OTTHUMG00000151620

Gene info

• Identity
  HGNC:5778
• Gene
  IGKV2-18
• Long gene name
  immunoglobulin kappa variable 2-18 (pseudogene)
• Synonyms gene name
  • immunoglobulin kappa variable 2-18
  • immunoglobulin kappa variable 2-18 pseudogene
• GenBank acession
  • X63400
• Locus
  2p11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28926
• RefSeq identity
  • NG_000834
• Classification
  • Immunoglobulin kappa locus at 2p11.2
• VEGA ID
  OTTHUMG00000151644

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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