RABBIT ANTI HRK

• Catalog number
  MBS221467
• Price
  Please ask
• Size
  5x0.1 mg

• Products_type
  Antibody
• Products_short_name
  [HRK]
• Other_names
  [activator of apoptosis harakiri; Activator of apoptosis harakiri; activator of apoptosis harakiri; BCL2-interacting protein; BH3-interacting domain-containing protein 3; activator of apoptosis Hrk; death protein 5; harakiri, BCL2 interacting protein (contains only BH3 domain); neuronal death protein DP5; harakiri, BCL2 interacting protein; BH3-interacting domain-containing protein 3; Neuronal death protein DP5]
• Products_gene_name
  [HRK]
• Other_gene_names
  [HRK; HRK; DP5; HARAKIRI; BID3]
• Clonality
  Polyclonal
• Reactivity
  Mouse, Rat
• Specificity
  This item detects Harakiri (HRK), also known as DP5. HRK is a BH3 only protein of the Bcl-2 family, which promotes Bax dependent apoptosis. HRK regulates apoptosis through its interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL, and in conjunction to the mitochondrial pore forming protein p32. HRK is thought to have a specific role in initiating neuronal and haematopoietic cell apoptosis, in particular to growth factor deprivation. Aberrant methylation of HRK is frequently detected in primary colorectal cancers. Despite its predicted molecular weight, HRK often migrates at 12-15kD.
• Form
  Purified Purified IgG - liquid
• Concentration
  IgG concentration 1.0mg/ml
• Storage_stability
  Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
• Tested_application
  Western Blot (WB)
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• About
  Rabbits are used for polyclonal antibody production by MyBioSource. Rabbit antibodies are very stable and can be stored for several days at room temperature. MyBioSource adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
• Latin name
  Oryctolagus cuniculus

• Gene target
  HRK  
• Gene symbol
  HRK
• Short name
  RABBIT ANTI HRK
• Technique
  Rabbit, anti, antibody to
• Host
  Rabbit, Rabbits
• Isotype
  IgG
• Alternative name
  production species: rabbit antibody to harakiri, BCL2 interacting protein (contains only BH3 domain)
• Alternative technique
  rabbit-anti, antibodies
• Alternative to gene target
  harakiri, BCL2 interacting protein (contains only BH3 domain), DP5 and HARAKIRI, HRK and IDBG-59297 and ENSG00000135116 and 8739, protein binding, Plasma membranes, Hrk and IDBG-195140 and ENSMUSG00000046607 and 12123, HRK and IDBG-633660 and ENSBTAG00000047484 and 787139

Gene info

• Identity
  HGNC:5185
• Gene
  HRK
• Long gene name
  harakiri, BCL2 interacting protein
• Synonyms gene name
  • harakiri, BCL2-interacting protein (contains only BH3 domain)
• Synonyms
  • DP5
• Synonyms name
  • death protein 5
• GenBank acession
  • U76376
• Locus
  12q24.22
• Discovery year
  1999-05-21
• Entrez gene record
  8739
• Pubmed identfication
  • 9130713
• Classification
  • BCL2 homology region 3 (BH3) only
• VEGA ID
  OTTHUMG00000169328

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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