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Products_type
Antibody
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Products_short_name
[CYCLIN E]
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Other_names
[G1/S-specific cyclin-E1; G1/S-specific cyclin-E1; G1/S-specific cyclin-E1; cyclin E variant ex5del; cyclin E variant ex7del; cyclin Es; cyclin Et; cyclin E1]
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Products_gene_name
[CYCLIN E]
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Other_gene_names
[CCNE1; CCNE1; CCNE; CCNE]
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Clonality
Polyclonal
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Reactivity
Mouse, Rat. N.B. Antibody reactivity and working conditions may vary between species.
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Specificity
This item detects cyclin E, a nuclear protein which is the regulatory subunit of cyclin dependent kinase 2 (Cdk2), and controls S phase entry in cells. Cyclin E follows a cyclic pattern of expression during the cell cycle, with highest expression at the G1-S boundary. Although cyclin E has an important physiological role in normal cell division, recent reports suggest this function is redundant, and its key functions occur as cells exit quiescence, and in endoreduplication. Cyclin E is tightly regulated during normal cell cycles, but is often deregulated in carcinomas, lymphoma, and leukaemia.
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Form
Serum Serum - liquid
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Storage_stability
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
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Tested_application
ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
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About
Rabbits are used for polyclonal antibody production by MyBioSource. Rabbit antibodies are very stable and can be stored for several days at room temperature. MyBioSource adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin name
Oryctolagus cuniculus
