Progesterone Receptor
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Catalog numberMBS438449
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PricePlease ask
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Size0.1 mg (Without BSA & Azide at 1mg/mL)
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Products_typeAntibody
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Products_short_name[Progesterone Receptor]
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Products_name_syn[NR3C3; Nuclear receptor subfamily 3 group C member 3; PGR; PR; PRA; PRB; Progesterone receptor form A; Progesterone receptor form B]
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Other_names[progesterone receptor isoform B; Progesterone receptor; progesterone receptor; nuclear receptor subfamily 3 group C member 3; progesterone receptor; Nuclear receptor subfamily 3 group C member 3]
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Products_gene_name[PGR]
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Other_gene_names[PGR; PGR; PR; NR3C3; NR3C3; PR]
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ClonalityMonoclonal
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Clone[PR500]
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ReactivityHuman.
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SpecificityThis MAb is specific to progesterone receptor and shows minimal cross-reaction with other members of the family. Progesterone receptor is expressed as two major isoforms, PR-A (81kDa) and PR-B (116kDa). Expression of PgR has been suggested to reflect a intact estrogen regulatory machinery and therefore, predict better clinical response to endocrine therapy than ER alone.
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Form200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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Storage_stabilityStore at 2 to 8 degree C. Antibody is stable for 24 months.
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Tested_applicationWestern Blot (WB), Immunohistology (IH)
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DescriptionThe receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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Gene target
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Gene symbolPGR, PGRMC2, PGRMC1
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Short nameProgesterone Receptor
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HostMouse
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IsotypeIgG1, kappa
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Alternative nameProgesterone Receptor
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Gene info
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Identity
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Gene
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Long gene nameprogesterone receptor
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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RefSeq identity
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Classification
- Nuclear receptor subfamily 3 group C
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameprogesterone receptor membrane component 2
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Synonyms
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Locus
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Discovery year2001-07-25
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Entrez gene record
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Pubmed identfication
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Classification
- Membrane associated progesterone receptor family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameprogesterone receptor membrane component 1
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Synonyms
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Locus
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Discovery year2001-07-25
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Membrane associated progesterone receptor family
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VEGA ID
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Locus Specific Databases