Progesterone Receptor

• Catalog number
  MBS438389
• Price
  Please ask
• Size
  0.1 mg (With BSA & Azide at 0.2mg/mL)

• Products_type
  Antibody
• Products_short_name
  [Progesterone Receptor]
• Products_name_syn
  [NR3C3; Nuclear receptor subfamily 3 group C member 3; PGR; PR; PRA; PRB; Progesterone receptor form A; Progesterone receptor form B]
• Other_names
  [progesterone receptor isoform B; Progesterone receptor; progesterone receptor; nuclear receptor subfamily 3 group C member 3; progesterone receptor; Nuclear receptor subfamily 3 group C member 3]
• Products_gene_name
  [PGR]
• Other_gene_names
  [PGR; PGR; PR; NR3C3; NR3C3; PR]
• Clonality
  Monoclonal
• Clone
  [PR501]
• Reactivity
  Human.
• Specificity
  This MAb is specific to progesterone receptor and shows minimal cross-reaction with other members of the family. Progesterone receptor is expressed as two major isoforms, PR-A (81kDa) and PR-B (116kDa). Expression of PgR has been suggested to reflect a intact estrogen regulatory machinery and therefore, predict better clinical response to endocrine therapy than ER alone.
• Form
  200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Storage_stability
  Store at 2 to 8 degree C. Antibody is stable for 24 months.
• Tested_application
  Western Blot (WB), Immunohistology (IH)
• Description
  The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

• Gene target
  Progesterone   Receptor  
• Gene symbol
  PGRMC2, PGR, PGRMC1
• Short name
  Progesterone Receptor
• Host
  Mouse
• Isotype
  IgG1, kappa
• Alternative name
  Progesterone Receptor

Gene info

• Identity
  HGNC:16089
• Gene
  PGRMC2
• Long gene name
  progesterone receptor membrane component 2
• Synonyms
  • PMBP
  • DG6
• Locus
  4q28.2
• Discovery year
  2001-07-25
• Entrez gene record
  10424
• Pubmed identfication
  • 9705155
• Classification
  • Membrane associated progesterone receptor family
• VEGA ID
  OTTHUMG00000133342

Gene info

• Identity
  HGNC:8910
• Gene
  PGR
• Long gene name
  progesterone receptor
• Synonyms
  • PR
  • NR3C3
• GenBank acession
  • M15716
• Locus
  11q22.1
• Discovery year
  2001-06-22
• Entrez gene record
  5241
• RefSeq identity
  • NM_000926
• Classification
  • Nuclear receptor subfamily 3 group C
• VEGA ID
  OTTHUMG00000167531

Gene info

• Identity
  HGNC:16090
• Gene
  PGRMC1
• Long gene name
  progesterone receptor membrane component 1
• Synonyms
  • HPR6.6
• Locus
  Xq24
• Discovery year
  2001-07-25
• Entrez gene record
  10857
• Pubmed identfication
  • 9705155
• RefSeq identity
  • NM_006667
• Classification
  • Membrane associated progesterone receptor family
• VEGA ID
  OTTHUMG00000022268
• Locus Specific Databases
  • Global Variome shared LOVD

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