NFkB Activating Kinase (Nuclear Factor kappa B, TANK-Binding Kinase 1, NAK, TBK1)
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Catalog number
MBS604330
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Price
Please ask
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Size
0.1 mg
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Products_type
Antibody
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Products_short_name
[NFkB Activating Kinase]
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Products_name_syn
[Anti -NFkB Activating Kinase (Nuclear Factor kappa B, TANK-Binding Kinase 1, NAK, TBK1)]
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Other_names
[NEDD4 family-interacting protein 1; NEDD4 family-interacting protein 1; NEDD4 family-interacting protein 1; Nedd4 WW domain-binding protein 5; putative MAPK-activating protein PM13; breast cancer-associated protein SGA-1M; putative NFKB and MAPK-activating protein; putative NF-kappa-B-activating protein 164; Nedd4 family interacting protein 1; Breast cancer-associated protein SGA-1M; NEDD4 WW domain-binding protein 5; Putative MAPK-activating protein PM13; Putative NF-kappa-B-activating protein 164; Putative NFKB and MAPK-activating protein]
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Other_gene_names
[NDFIP1; NDFIP1; N4WBP5; N4WBP5]
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Clonality
Monoclonal
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Clone
[4H209]
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Reactivity
Mouse
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Specificity
NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus (1). External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated (2). IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g (3-5). IKK1/a and IKK2/b are phosphorylated by NF-kB-inducing kinase (NIK) (6) and MAP kinase kinase kinase-1 (MEKK1) (7), respectively. Recently, a new IKK family member, TBK1 (TANK-binding kinase) has been identified (8). TANK (TRAF-associated NF-kB activator) interacts with TBK1 and activates NF-kB in a kinase dependent manner.
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Purity
Affinity Purified Purified by Protein G affinity chromatography.
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Form
Supplied as a liquid in PBS, 0.02% sodium azide.
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Storage_stability
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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Tested_application
Western Blot (WB)
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Description
Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.
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Gene
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (κ light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory
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Gene target
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Gene symbol
TBK1, TANK-AS1, TANK, NR4A1
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Short name
NFkB Activating Kinase ( Factor kappa B, TANK-Binding Kinase 1, NAK, TBK1)
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Host
Mouse
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Isotype
IgG1
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Alternative name
NFkB Activating phosphorylation catalyst (Nuclear Factor kappa B, TANK-Binding phosphorylation catalyst 1, NAK, TANK-binding kinase 1)
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Alternative to gene target
TANK-binding kinase 1, TBK1 and IDBG-44993 and ENSG00000183735 and 29110, transferase activity, Cytoplasm, Tbk1 and IDBG-192882 and ENSMUSG00000020115 and 56480, TBK1 and IDBG-634420 and ENSBTAG00000017401 and 533141
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Gene info
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Identity
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Gene
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Long gene name
TANK binding kinase 1
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Synonyms gene name
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Synonyms
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GenBank acession
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Locus
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Discovery year
2000-06-08
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene name
TANK antisense RNA 1
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Locus
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Discovery year
2020-03-27
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Entrez gene record
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Classification
Gene info
Gene info
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