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Products_type
Antibody
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Products_short_name
[CASP1 / Caspase 1]
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Products_name_syn
[Anti-CASP1 / Caspase 1 Antibody (aa371-390, clone 14F468) IHC-plus; CASP1; Caspase-1; CASP-1; CASP1 nirs variant 1; Caspase 1; ICE; ICE-like protease; IL-1 beta-converting enzyme; IL-1BC; IL1BC; IL1BCE; p45; IL1B-convertase; Interleukin-1 beta convertase; Human CASP1; Caspase 1]
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Other_names
[caspase-1 isoform beta; Caspase-1; caspase-1; IL1B-convertase; CASP1 nirs variant 1; IL-1 beta-converting enzyme; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); caspase 1, apoptosis-related cysteine peptidase; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45Cleaved into the following 2 chains:Caspase-1 subunit p20; Caspase-1 subunit p10]
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Products_gene_name
[CASP1]
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Other_gene_names
[CASP1; CASP1; ICE; P45; IL1BC; IL1BC; IL1BCE; CASP-1; IL-1BC; ICE; IL-1 beta-converting enzyme]
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Clonality
Monoclonal
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Clone
[14F468]
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Reactivity
Gibbon, Gorilla, Human Predicted Reactivity: Rat, Bat (at least 90% immunogen sequence identity)
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Specificity
A synthetic peptide corresponding to amino acids 371-390 RKVRFSFEQPDGRAQMPTTE of human caspase-1 was used as immunogen. It will cross-react with mouse and rat Caspase-1, based on NCBI BLAST.
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Purity
Protein G Purified
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Form
PBS, 0.05% BSA, 0.05% sodium azide.
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Concentration
0.5 mg/ml
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Storage_stability
+4 degree C or -20 degree C, Avoid repeated freezing and thawing.
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Tested_application
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
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Description
Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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About
Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
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Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus
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Gene target
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Gene symbol
CASP1
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Short name
Mouse Monoclonal [clone 14F468] (IgG1) CASP1 / Caspase 1
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Technique
Mouse monoclonal, Mouse, Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
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Host
Mouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
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Isotype
IgG1, IgG1
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Species
Human, Humans, Mouses
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Alternative name
Mouse monoclonal [clonality 14F468] (IgG1) to H. sapiens caspase 1, apoptosis-related cysteine peptidase / caspase 1
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Alternative technique
murine
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Alternative to gene target
caspase 1, apoptosis-related cysteine peptidase, ICE and IL1BC and P45, CASP1 and IDBG-69618 and ENSG00000137752 and 834, cysteine-type endopeptidase activator activity involved in apoptotic process, Extracellular, Casp1 and IDBG-131590 and ENSMUSG00000025888 and 12362
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Clone name
14F468
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